Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency
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DOI: 10.1038/s41588-025-02125-1
Abstract: Somatic variants accumulate in non-malignant tissues with age. Functional variants, leading to clonal advantage of hepatocytes, accumulate in the liver of patients with acquired chronic liver disease (CLD). Whether somatic variants are common to CLD… read more here.
Keywords: alpha antitrypsin; variants serpina1; somatic variants; somatic escape ... See more keywords