Determining the Origin of Human Germinal Center B Cell-Derived Malignancies.
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DOI: 10.1007/978-1-4939-7095-7_20
Abstract: Most human B cell lymphomas originate from germinal center (GC) B cells. This is partly caused by the high proliferative activity of GC B cells and the remodeling processes acting at the immunoglobulin (Ig) loci… read more here.
Keywords: germinal center; gene; cell; somatic hypermutation ... See more keywords
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells
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DOI: 10.1038/s41588-020-00772-0
Abstract: Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA exoribonuclease in mammalian cells, is composed of nine core and two catalytic… read more here.
Keywords: noncoding rna; rna; rna processing; dis3 ... See more keywords
What Targets Somatic Hypermutation to the Immunoglobulin Loci?
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DOI: 10.1089/vim.2019.0149
Abstract: One of the most profound enigmas in B cell biology is how activation-induced deaminase (AID) is targeted to a very small region of DNA in the immunoglobulin loci. Two specific regions are singled out: the… read more here.
Keywords: immunoglobulin loci; transcription; aid; somatic hypermutation ... See more keywords
A somatic hypermutation–based machine learning model stratifies individuals with Crohn's disease and controls
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DOI: 10.1101/gr.276683.122
Abstract: Crohn's disease (CD) is a chronic relapsing–remitting inflammatory disorder of the gastrointestinal tract that is characterized by altered innate and adaptive immune function. Although massively parallel sequencing studies of the T cell receptor repertoire identified… read more here.
Keywords: disease; machine learning; somatic hypermutation; crohn disease ... See more keywords
V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation
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DOI: 10.1111/imm.13176
Abstract: Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds of antigens owing to the extreme diversity of their antigen‐binding portions, known as variable (V) regions, play an important role in immune responses.… read more here.
Keywords: mechanism; diversity; class; recombination ... See more keywords
Somatic Hypermutation and Framework Mutations of Variable Region Contribute to Anti-Zika Virus-Specific Monoclonal Antibody Binding and Function
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DOI: 10.1128/jvi.00071-22
Abstract: ZIKV is a global health concern against which no vaccine or therapeutics are available. We characterized eight novel rabbit monoclonal antibodies recognizing ZIKV envelope and prM proteins and studied the relationship between somatic hypermutation of… read more here.
Keywords: somatic hypermutation; region; framework; zikv ... See more keywords
SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis.
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DOI: 10.1158/2159-8290.cd-21-1514
Abstract: SETD2 is the sole histone methyltransferase responsible for H3K36me3, with roles in splicing, transcription initiation and DNA damage response. Homozygous disruption of SETD2 yields a tumor suppressor effect in various cancers. However, SETD2 mutation is… read more here.
Keywords: lymphomagenesis; dna damage; somatic hypermutation; setd2 haploinsufficiency ... See more keywords
A novel next-generation sequencing capture-based strategy to report somatic hypermutation status using genomic regions downstream to immunoglobulin rearrangements
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.281928
Abstract: The somatic hypermutation (SHM) status of the clonotypic, rearranged immunoglobulin heavy variable (IGHV) gene is an established prognostic and predictive marker in chronic lymphocytic leukemia (CLL). Analysis of SHM is generally performed by polymerase chain… read more here.
Keywords: shm; somatic hypermutation; status; strategy ... See more keywords
Mutating for Good: DNA Damage Responses During Somatic Hypermutation
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DOI: 10.3389/fimmu.2019.00438
Abstract: Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies. In this way SHM is key in… read more here.
Keywords: dna damage; somatic hypermutation; shm; dna ... See more keywords
Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line
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DOI: 10.3389/fimmu.2022.871766
Abstract: Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a B cell specific process required for the generation of specific and high affinity antibodies during the maturation of the immune response against foreign antigens. This process… read more here.
Keywords: pcna; cell; cell line; ramos cell ... See more keywords
Rapid Hypermutation B Cell Trajectory Recruits Previously Primed B Cells Upon Third SARS-Cov-2 mRNA Vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.876306
Abstract: High antibody affinity against the ancestral SARS-CoV-2 strain seems to be necessary (but not always sufficient) for the control of emerging immune-escape variants. Therefore, aiming at strong B cell somatic hypermutation - not only at… read more here.
Keywords: cell; vaccination; somatic hypermutation; immune escape ... See more keywords