LAUSR

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

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1 Published in 2017 at "Human Mutation"

DOI: 10.1002/humu.23157

Abstract: MED12 is a key component of the transcription‐regulating Mediator complex. Specific missense and in‐frame insertion/deletion mutations in exons 1 and 2 have been identified in uterine leiomyomas, breast tumors, and chronic lymphocytic leukemia. Here, we… read more here.

Keywords: nonsense mutation; somatic med12; med12; mrna decay ... See more keywords