Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis
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DOI: 10.1126/sciadv.ads8489
Abstract: The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on this process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from… read more here.
Keywords: mutation burden; metabolic plasticity; somatic mtdna; mtdna mutation ... See more keywords
Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells
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DOI: 10.1126/sciadv.adt3873
Abstract: Somatic mitochondrial DNA (mtDNA) mutations are frequently observed in tumors, yet their role in pediatric cancers remains poorly understood. The heteroplasmic nature of mtDNA—where mutant and wild-type mtDNA coexist—complicates efforts to define its contribution to… read more here.
Keywords: mtdna; leukemic cells; functional heterogeneity; source functional ... See more keywords
Abstract SY27-02: Exploring the significance of somatic mtDNA mutations in the context of acute leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-sy27-02
Abstract: Somatic mitochondrial DNA (mtDNA) mutations are commonly observed in tumors, yet their functional role in pediatric cancers remains largely unexplored. The unique biology of mtDNA—including its heteroplasmic nature, where mutant and wild-type mtDNA coexist—poses challenges… read more here.
Keywords: mtdna; exploring significance; somatic mtdna; biology ... See more keywords