The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13275
Abstract: Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with expanded clones that are frequently driven by cancer‐associated mutations in an… read more here.
Keywords: somatic mutational; mutational landscapes; disease; cancer ... See more keywords
Somatic mutational landscape of extracranial arteriovenous malformations and phenotypic correlations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18046
Abstract: Somatic genetic variants may be the cause of extracranial arteriovenous malformations, but few studies have explored these genetic anomalies, and no genotype–phenotype correlations have been identified. read more here.
Keywords: landscape extracranial; somatic mutational; extracranial arteriovenous; malformations phenotypic ... See more keywords
Profiling the somatic mutational landscape of breast tumors from Hispanic/Latina women reveals conserved and unique characteristics.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2510
Abstract: Somatic mutational profiling is increasingly being used to identify potential targets for breast cancer. However, limited tumor-sequencing data from Hispanic/Latinas (H/L) are available to guide treatment. To address this gap, we performed whole exome sequencing… read more here.
Keywords: somatic mutational; breast; breast tumors; white women ... See more keywords
Does breast carcinoma belong to the Lynch syndrome tumor spectrum? – Somatic mutational profiles vs. ovarian and colorectal carcinomas
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DOI: 10.18632/oncotarget.27538
Abstract: Inherited DNA mismatch repair (MMR) defects cause predisposition to colorectal, endometrial, ovarian, and other cancers occurring in Lynch syndrome (LS). It is unsettled whether breast carcinoma belongs to the LS tumor spectrum. We approached this… read more here.
Keywords: carcinomas; breast; cancer; somatic mutational ... See more keywords
The somatic mutational landscape and role of the ARID1A gene in hepatocellular carcinoma
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DOI: 10.2139/ssrn.4095314
Abstract: Introduction Hepatocellular carcinoma (HCC) is one of the most common malignant tumours worldwide. Clarification of the somatic mutational landscape of important genes could reveal new therapeutic targets and facilitate individualized therapeutic approaches for HCC patients.… read more here.
Keywords: role arid1a; hepatocellular carcinoma; somatic mutational; hcc ... See more keywords