LAUSR

Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition

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0 Published in 2024 at "Angiogenesis"

DOI: 10.1007/s10456-024-09934-8

Abstract: Arteriovenous malformations (AVM) are benign vascular anomalies prone to pain, bleeding, and progressive growth. AVM are mainly caused by mosaic pathogenic variants of the RAS-MAPK pathway. However, a causative variant is not identified in all… read more here.

Keywords: arteriovenous malformations; mapk signaling; ras mapk; somatic rit1 ... See more keywords