Detection of somatic structural variants from short-read next-generation sequencing data
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaa056
Abstract: Abstract Somatic structural variants (SVs), which are variants that typically impact >50 nucleotides, play a significant role in cancer development and evolution but are notoriously more difficult to detect than small variants from short-read next-generation… read more here.
Keywords: short read; detection; read next; structural variants ... See more keywords
G-Quadruplex Structures Are Key Modulators of Somatic Structural Variants in Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-3089
Abstract: G-quadruplex structure formation constitutes a critical step in the production of somatic structural variants in cancers, suggesting G-quadruplex structures as potential targets for future cancer prevention and treatment strategies. read more here.
Keywords: somatic structural; key modulators; quadruplex structures; variants cancers ... See more keywords