Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons
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DOI: 10.1038/s41598-021-03608-x
Abstract: The inhibition of voltage-gated sodium (NaV) channels in somatosensory neurons presents a promising novel modality for the treatment of pain. However, the precise contribution of these channels to neuronal excitability, the cellular correlate of pain,… read more here.
Keywords: excitability; somatosensory neurons; pluripotent stem; stem cell ... See more keywords
Inhibitory Gi/O-coupled receptors in somatosensory neurons: Potential therapeutic targets for novel analgesics
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DOI: 10.1177/1744806918763646
Abstract: Primary sensory neurons in the dorsal root ganglia and trigeminal ganglia are responsible for sensing mechanical and thermal stimuli, as well as detecting tissue damage. These neurons express ion channels that respond to thermal, mechanical,… read more here.
Keywords: neurons potential; somatosensory neurons; coupled receptors; receptors somatosensory ... See more keywords
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202154313
Abstract: Somatosensory neurons are highly heterogeneous with distinct types of neural cells responding to specific stimuli. However, the distribution and roles of cell‐type‐specific long intergenic noncoding RNAs (lincRNAs) in somatosensory neurons remain largely unexplored. Here, by… read more here.
Keywords: somatosensory neurons; type specific; lincrna clap; clap ... See more keywords
Somatosensory neurons integrate the geometry of skin deformation and mechanotransduction channels to shape touch sensing
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.43226
Abstract: Touch sensation hinges on force transfer across the skin and activation of mechanosensitive ion channels along the somatosensory neurons that invade the skin. This skin-nerve sensory system demands a quantitative model that spans the application… read more here.
Keywords: integrate geometry; neurons integrate; somatosensory neurons; geometry ... See more keywords