A randomised, multicentre trial of somatostatin to prevent clinically relevant postoperative pancreatic fistula in intermediate-risk patients after pancreaticoduodenectomy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-021-01818-8
Abstract: Prophylactic somatostatin to reduce the incidence of clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy remains controversial. We assessed the preventive efficacy of somatostatin on clinically relevant postoperative pancreatic fistula in intermediate-risk patients who underwent pancreaticoduodenectomy… read more here.
Keywords: pancreatic fistula; postoperative pancreatic; clinically relevant; fistula ... See more keywords
Evaluation of 68Ga-DOTATATE uptake at the pituitary region and the biochemical response to somatostatin analogs in acromegaly
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-021-01523-6
Abstract: Acromegaly is associated with many comorbidities and increased mortality. The first-line treatment is transsphenoidal surgery. However, many patients also need adjuvant drug treatment after surgery. Somatostatin analog (SSA), which suppresses GH secretion by somatotrophs by… read more here.
Keywords: response; treatment; dotatate uptake; pituitary region ... See more keywords
Dynamical Behavior of Somatostatin-14 and Its Cyclic Analogues as Analyzed in Bulk and on Plasmonic Silver Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2018.01.002
Abstract: Primarily known as the inhibitor of growth hormone release, the role of somatostatin in many other inhibiting activities upon binding to its five G-protein-coupled receptors has been elucidated. Because of the short half-life of somatostatin,… read more here.
Keywords: silver nanoparticles; cyclic analogues; behavior somatostatin; dynamical behavior ... See more keywords
Postsynaptic GABABRs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2017.12.021
Abstract: Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAA and metabotropic GABAB receptors (GABABRs). Despite GABABRs representing a major source of inhibition, little is known of their function in distinct IN subtypes. Here, we… read more here.
Keywords: calcium; long term; term potentiation; somatostatin ... See more keywords
Small molecule somatostatin receptor subtype 4 (sst4) agonists are novel anti-inflammatory and analgesic drug candidates
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108198
Abstract: We provided strong proof of concept evidence that somatostatin mediates potent analgesic and anti-inflammatory actions via its receptor subtype 4 (sst4) located both at the periphery and the central nervous system. Therefore, sst4 agonists are… read more here.
Keywords: anti inflammatory; drug; sst4 agonists; receptor ... See more keywords
Somatostatin Receptor as a Molecular Imaging Target in Human and Canine Cushing's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "World neurosurgery"
DOI: 10.1016/j.wneu.2021.02.034
Abstract: OBJECTIVES Fluorescence-guided surgery (FGS) may improve completeness of resection in transsphenoidal surgery for Cushing's Disease (CD) by enabling visualization of residual tumor tissue at the margins. In this review we discuss somatostatin receptors (SSTRs) as… read more here.
Keywords: sstr expression; cushing disease; canine; expression ... See more keywords
Activation of cortical somatostatin interneurons prevents the development of neuropathic pain
Sign Up to like & getrecommendations! Published in 2017 at "Nature neuroscience"
DOI: 10.1038/nn.4595
Abstract: Neuropathic pain involves long-lasting modifications of pain pathways that result in abnormal cortical activity. How cortical circuits are altered and contribute to the intense sensation associated with allodynia is unclear. Here we report a persistent… read more here.
Keywords: neuropathic pain; activation; somatostatin; pyramidal neuron ... See more keywords
Cyclooxygenase-2 up-regulates hepatic somatostatin receptor 2 expression
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29349-y
Abstract: Somatostatin and its analogues, which function by binding to somatostatin receptors (SSTRs) 1–5, play a protective role in liver cirrhosis. Hepatic SSTR-2 expression is up-regulated in subjects with liver cirrhosis. However, little is known about… read more here.
Keywords: sstr expression; hepatic sstr; expression; somatostatin ... See more keywords
Interaction of neuropeptide Y receptors (NPY1, NPY2 and NPY5) with somatostatin on somatostatin-induced feeding behaviour in neonatal chicken
Sign Up to like & getrecommendations! Published in 2019 at "British Poultry Science"
DOI: 10.1080/00071668.2018.1547359
Abstract: ABSTRACT 1. The present study was conducted to investigate whether brain somatostatin increases feed intake in neonatal chickens. The mediating role of neuropeptide Y receptors on feed intake induced by somatostatin was investigated. 2. In… read more here.
Keywords: sml0891; feed intake; injection; receptor ... See more keywords
Growth and carcass trait association with variation in the somatostatin receptor 1 (SSTR1) gene in New Zealand Romney sheep
Sign Up to like & getrecommendations! Published in 2018 at "New Zealand Journal of Agricultural Research"
DOI: 10.1080/00288233.2017.1415942
Abstract: ABSTRACT Somatostatin receptors (SSTRs) are thought to regulate the growth inhibitory effect of somatostatin and play a role in regulating growth hormone secretion. In this study, polymerase chain reaction-single-stranded conformational polymorphism (PCR-SSCP) analysis was used… read more here.
Keywords: new zealand; zealand romney; sstr1 gene; somatostatin ... See more keywords
Early Excitatory Activity-Dependent Maturation of Somatostatin Interneurons in Cortical Layer 2/3 of Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral cortex"
DOI: 10.1093/cercor/bhy293
Abstract: GABAergic interneurons perform distinct functions during cortical development in the mouse brain. Among the diverse GABAergic neurons present in the brain, early-born somatostatin (SST)-expressing inhibitory interneurons, which are innervated by other interneurons and local pyramidal… read more here.
Keywords: sst interneurons; maturation; early excitatory; activity ... See more keywords