Cardiovascular magnetic resonance imaging and clinical performance of somatostatin receptor positron emission tomography in cardiac sarcoidosis
Sign Up to like & getrecommendations! Published in 2018 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12243
Abstract: Cardiac affection constitutes a major limiting condition in systemic sarcoidosis. The primary objective of this study was to investigate the persistence rate of cardiac sarcoid involvement by cardiovascular magnetic resonance (CMR) imaging in patients diagnosed… read more here.
Keywords: magnetic resonance; somatostatin receptor; sarcoidosis; cardiac sarcoidosis ... See more keywords
Fluorescence imaging of meningioma cells with somatostatin receptor ligands: an in vitro study
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-019-03872-x
Abstract: BackgroundThe use of five-aminolevulinic acid (5-ALA) in the staining of malignant glioma cells has significantly improved intraoperative radicality in the resection of gliomas in the last decade. Currently, there is no comparable selective fluorescent substance… read more here.
Keywords: fluorescence; somatostatin receptor; meningioma; receptor ... See more keywords
Pasireotide—a novel somatostatin receptor ligand after 20 years of use
Sign Up to like & getrecommendations! Published in 2022 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-022-09710-3
Abstract: Pasireotide, a novel multireceptor-targeted somatostatin receptor ligand (SRL) is characterized by a higher affinity to somatostatin receptor type 5 than type 2, unlike first-generation SRLs. Because of the broader binding profile, pasireotide has been suggested… read more here.
Keywords: somatostatin receptor; pasireotide novel; receptor ligand; cushing disease ... See more keywords
Training on Reporting and Data System (RADS) for Somatostatin-Receptor Targeted Molecular Imaging Can Reduce the Test Anxiety of Inexperienced Readers
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-022-01712-6
Abstract: For somatostatin receptor (SSTR)-positron emission tomography/computed tomography (PET/CT), a standardized framework termed SSTR-reporting and data system (RADS) has been proposed. We aimed to elucidate the impact of a RADS-focused training on reader’s anxiety to report… read more here.
Keywords: system; anxiety; somatostatin receptor; sstr pet ... See more keywords
Somatostatin receptor profile in pituitary thyrotroph adenomas
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2020.105865
Abstract: OBJECTIVES Thyrotroph adenomas are the most infrequent adenohypophysial tumors. Somatostatin (SST) inhibits hormone secretion and suppresses cell proliferation. SST receptors (sstr) belong to a family of 5 types of G-coupled membrane proteins, which show high… read more here.
Keywords: thyrotroph adenomas; sst analogs; adenomas; somatostatin receptor ... See more keywords
Ligand design for somatostatin receptor isoforms 4 and 5.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.030
Abstract: The somatostatin receptor (SSTR) isoforms, SSTR-4 and SSTR-5 are targets in numerous disorders and diseases. Although there has been some success in achieving selective isoform inhibition, structure-based drug design and development in this area has… read more here.
Keywords: somatostatin receptor; sstr sstr; design;
High-Contrast Detection of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00583
Abstract: Dye design can influence the ability of fluorescently labeled imaging agents to generate tumor contrast and has become an area of significant interest in the field of fluorescence-guided surgery (FGS). Here, we show that the… read more here.
Keywords: contrast; fnir tag; fluorescence guided; somatostatin receptor ... See more keywords
Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00306
Abstract: A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing a subseries showed improvement in their metabolic… read more here.
Keywords: somatostatin receptor; optimization preclinical; preclinical metabolism; receptor subtype ... See more keywords
Somatostatin receptor expression related to TP53 and RB1 alterations in pancreatic and extrapancreatic neuroendocrine neoplasms with a Ki67-index above 20%
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.217
Abstract: Somatostatin receptor 2A expression is a feature of well-differentiated neuroendocrine neoplasms and is important for their diagnosis and therapy. Little is known about somatostatin receptor 2A expression in poorly differentiated neuroendocrine neoplasms in relation to… read more here.
Keywords: somatostatin receptor; poorly differentiated; neuroendocrine neoplasms; differentiated neuroendocrine ... See more keywords
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20308-8
Abstract: Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor… read more here.
Keywords: epstein barr; induced epstein; somatostatin receptor; barr virus ... See more keywords
Toward a better understanding of the interaction between somatostatin receptor 2 and its ligands: a structural characterization study using molecular dynamics and conceptual density functional theory
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1508368
Abstract: Abstract This study is a part of the extensive research intending to provide the structural insights on somatostatin and its receptor. Herein, we have studied the structural complexity involved in the binding of somatostatin receptor… read more here.
Keywords: theory; study; somatostatin receptor; receptor ... See more keywords