Structural characterization of 14-3-3ΞΆ in complex with the human Son of sevenless homolog 1 (SOS1).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2018.01.011
Abstract: The deviant Ras activation machinery is found in approximately 30% of all human cancers. SOS1 is an important protagonist of this pathway that plays a key-role in aberrant cell proliferation and differentiation. Interaction of SOS1… read more here.
Keywords: complex human; son sevenless; human son; sos1 ... See more keywords
Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2021.1952984
Abstract: IntroductionUp to 30% of all human cancers are driven by the overactivation of RAS signaling. Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents… read more here.
Keywords: son sevenless; small molecule; sos1; sevenless sos1 ... See more keywords
Enhanced expression of son of sevenless homolog 1 is predictive of poor prognosis in uveal malignant melanoma patients
Sign Up to like & getrecommendations! Published in 2019 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2019.1573904
Abstract: ABSTRACT Purpose: The work outlined herein investigated the prognosis value and the potential role son of sevenless homolog 1 (SOS1) played in uveal melanoma (UM). Methods: We analyzed the mRNA expression level of SOS1 in… read more here.
Keywords: son sevenless; prognosis; expression; sos1 ... See more keywords