Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
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DOI: 10.1021/acsomega.9b03459
Abstract: The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein-protein interactions. The substituted variants of the Sondheimer dialkyne can be used to generate… read more here.
Keywords: sondheimer dialkyne; strain promoted; stapled peptide; p53 mdm2 ... See more keywords