The Sonic Hedgehog signaling pathway regulates autophagy and migration in ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4018
Abstract: The Sonic Hedgehog (SHH) signaling pathway plays an important role in various types of human cancers including ovarian cancer; however, its function and underlying mechanism in ovarian cancer are still not entirely understood. read more here.
Keywords: cancer; signaling pathway; ovarian cancer; sonic hedgehog ... See more keywords
Sonic hedgehog expression in zebrafish forebrain identifies the teleostean pallidal signaling center and shows preglomerular complex and posterior tubercular dopamine cells to arise from shh cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24825
Abstract: Ventralization, a major patterning process in the developing vertebrate neural tube (central nervous system, CNS), depends on Sonic hedgehog (SHH) as a main signaling morphogen. We studied the CNS of late larval and young adult… read more here.
Keywords: shh gfp; dopamine; shh; sonic hedgehog ... See more keywords
Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.555
Abstract: Frem1 has been linked to human face shape variation, dysmorphology, and malformation, but little is known about its regulation and biological role in facial development. read more here.
Keywords: hedgehog signaling; activity regulated; sonic hedgehog; frem1 activity ... See more keywords
Argininosuccinate synthase 1 and periportal gene expression in sonic hedgehog hepatocellular adenomas
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29884
Abstract: Genetic alterations define different molecular subclasses of hepatocellular adenoma (HCA) linked with risk factors, histology and clinical behavior. Recently, Argininosuccinate Synthase 1 (ASS1), a major periportal protein, was proposed as a marker of HCA with… read more here.
Keywords: sonic hedgehog; hca; expression; ass1 expression ... See more keywords
Role of Sonic hedgehog signaling in cell cycle, oxidative stress, and autophagy of temozolomide resistant glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29274
Abstract: The first‐line chemotherapy treatment for Glioblastoma (GBM) ‐ the most aggressive and frequent brain tumor ‐ is temozolomide (TMZ). The Sonic hedgehog (SHH) pathway is involved with GBM tumorigenesis and TMZ chemoresistance. The role of… read more here.
Keywords: glioblastoma; tmz; role; sonic hedgehog ... See more keywords
Dysregulations of sonic hedgehog signaling in MED12‐related X‐linked intellectual disability disorders
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.569
Abstract: Mutations in mediator of RNA polymerase II transcription subunit 12 homolog (MED12, OMIM 300188) cause X‐linked intellectual disability (XLID) disorders including FG, Lujan, and Ohdo syndromes. The Gli3‐dependent Sonic Hedgehog (SHH) signaling pathway has been… read more here.
Keywords: intellectual disability; linked intellectual; med12; sonic hedgehog ... See more keywords
A novel finding of an IDH2 mutation in an interesting adult Sonic Hedgehog mutated medulloblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03207-x
Abstract: We report the case of a 29-year-old female who presented with headaches and papilledema and found to have a right cerebellar T2/FLAIR hyperintense mass with restricted diffusion and minimal patchy enhancement resulting in fourth ventricular… read more here.
Keywords: adult; medulloblastoma; missense mutation; sonic hedgehog ... See more keywords
Theophylline increases saliva sonic hedgehog and improves taste dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.06.022
Abstract: OBJECTIVE To determine changes in saliva sonic hedgehog (Shh) and in taste dysfunction before and after oral theophylline treatment. DESIGN Shh was measured in parotid saliva of both normal subjects and patients with taste dysfunction… read more here.
Keywords: taste; saliva sonic; taste dysfunction; theophylline ... See more keywords
Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.01.018
Abstract: Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their roles in tumorigenesis remain unclear. The… read more here.
Keywords: gpr161; protein coupled; pathway; shh ... See more keywords
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Cell"
DOI: 10.1016/j.devcel.2017.12.003
Abstract: Summary To uncover regulatory mechanisms in Hedgehog (Hh) signaling, we conducted genome-wide screens to identify positive and negative pathway components and validated top hits using multiple signaling and differentiation assays in two different cell types.… read more here.
Keywords: cell sensitivity; hedgehog; sonic hedgehog; cell ... See more keywords
Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental cell"
DOI: 10.1016/j.devcel.2022.02.008
Abstract: The dually lipidated Sonic hedgehog (SHH) morphogen signals through the tumor suppressor membrane protein Patched1 (PTCH1) to activate the Hedgehog pathway, which is fundamental in development and cancer. SHH engagement with PTCH1 requires the GAS1… read more here.
Keywords: ptch1; patched1; shh ptch1; sonic hedgehog ... See more keywords