Ultrasound‐Triggered Nano‐Bomb: Bacteria‐Targeted Oxygen‐Supplying Liposomes as Seed Bubbles for Enhanced Mechano‐Sonodynamic Therapy of Pseudomonas aeruginosa Biofilms
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DOI: 10.1002/adfm.202501347
Abstract: Biofilms are the primary form of infections caused by bacterial pathogens such as Pseudomonas aeruginosa (P. aeruginosa). Encased in extracellular polymeric substances, biofilms form a sealed, dense, and hypoxic microenvironmental barrier, limiting antibiotic penetration, impairing… read more here.
Keywords: seed; oxygen; aeruginosa; sonodynamic therapy ... See more keywords
Ultrasound‐Propelled Nanomotors Enable Activatable Near‐Infrared‐II Fluorescence Imaging‐Guided Synergistic Oxygen‐Independent and Oxygen‐Dependent Sonodynamic Therapy of Atherosclerosis
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DOI: 10.1002/adfm.202503885
Abstract: Sonodynamic therapy (SDT) holds great promise as a therapeutic approach for treating atherosclerotic plaque. However, the therapeutic efficacy of SDT is hindered by the restricted tissue penetration depth and insufficient generation of reactive oxygen species… read more here.
Keywords: imaging guided; oxygen; fluorescence; sonodynamic therapy ... See more keywords
pH/Ultrasound Dual‐Responsive Gas Generator for Ultrasound Imaging‐Guided Therapeutic Inertial Cavitation and Sonodynamic Therapy
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DOI: 10.1002/adhm.201700957
Abstract: Herein, a pH/ultrasound dual-responsive gas generator is reported, which is based on mesoporous calcium carbonate (MCC) nanoparticles by loading sonosensitizer (hematoporphyrin monomethyl ether (HMME)) and modifying surface hyaluronic acid (HA). After pinpointing tumor regions with… read more here.
Keywords: cavitation; dual responsive; ultrasound dual; responsive gas ... See more keywords
Effective Sonosensitizer Delivery by Redox Sensitive Nanoparticles for Prostate Cancer Sonodynamic Therapy via Amplifying Oxidative Stress and Peroxidation
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DOI: 10.1002/adhm.202201472
Abstract: Sonodynamic therapy (SDT), a novel noninvasive therapeutic modality, provides many noteworthy benefits by generating reactive oxygen species (ROS). However, water‐insoluble sonosensitizer delivery strategies have continuously underperformed because of unavoidable toxicity and a short circulation time.… read more here.
Keywords: stress; prostate cancer; sonosensitizer; oxidative stress ... See more keywords
Recent Developments of Inorganic Nano-sensitizers for Sonodynamic Therapy.
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DOI: 10.1002/adhm.202300234
Abstract: As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because of its ability to penetrate deep tissue with few side effects. As the key factor of SDT, it… read more here.
Keywords: inorganic nano; recent developments; inorganic sonosensitizers; developments inorganic ... See more keywords
In Vitro Sonodynamic Therapy Using a High Throughput 3D Glioblastoma Spheroid Model with 5‐ALA and TMZ Sonosensitizers
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DOI: 10.1002/adhm.202402877
Abstract: Sonodynamic therapy (SDT) administered using low‐intensity pulsed ultrasound and sonosensitizers is an emerging, minimally invasive, targeted deep‐tissue therapy for solid tumors such as glioblastoma multiforme (GBM). Initial clinical trials show promising outcomes for SDT treatments… read more here.
Keywords: high throughput; ala tmz; therapy; sonodynamic therapy ... See more keywords
In Situ Self‐Assembly Enhanced Cavitation for Efficient Sonodynamic Therapy of Tumors
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DOI: 10.1002/adhm.202501655
Abstract: The clinical application of sonodynamic therapy (SDT) is constrained due to the lack of safe, effective, and targeted ultrasound sensitizers. To address this, an in situ self‐assembled peptide‐sonosensitizer conjugate (P1) is designed for enhancing sonosensitizer… read more here.
Keywords: unit; cavitation; sonodynamic therapy; self assembly ... See more keywords
Open‐Shell Nanosensitizers for Glutathione Responsive Cancer Sonodynamic Therapy
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DOI: 10.1002/adma.202110283
Abstract: Deleterious effects to normal tissues and short biological half‐life of sonosensitizers limit the applications of sonodynamic therapy (SDT). Herein, a new sonosensitizer (Cu(II)NS) is synthesized that consists of porphyrins, chelated Cu2+, and poly(ethylene glycol) (PEG)… read more here.
Keywords: shell nanosensitizers; sonodynamic therapy; cancer; open shell ... See more keywords
Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity
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DOI: 10.1002/adma.202206594
Abstract: The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field of cancer treatment. Herein, a new strategy for the development of efficient organic sonosensitizers based on triarylboron‐doped acenethiophene scaffolds is… read more here.
Keywords: organic sonosensitizers; phototoxicity; doped acenethiophenes; low phototoxicity ... See more keywords
Dual-Enhanced Sonodynamic Therapy: Synergizing Cavitation Amplification and Efficient Sonoluminescence-to-ROS Conversion for Orthotopic Breast Cancer Treatment.
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DOI: 10.1002/adma.202516803
Abstract: Sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality with superior penetration depth, receives tremendous attention. To date, the widely accepted mechanism for reactive oxygen species (ROS) generation in SDT involves acoustic cavitation-triggered sonoluminescence (SL),… read more here.
Keywords: cavitation; dual enhanced; sonodynamic therapy; ros conversion ... See more keywords
Enhancing Penetration Ability of Semiconducting Polymer Nanoparticles for Sonodynamic Therapy of Large Solid Tumor
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DOI: 10.1002/advs.202104125
Abstract: Sonodynamic therapy (SDT) holds growing promise in deep‐seated or large solid tumor treatment owing to its high tissue penetration depth ability; however, its therapeutic efficacy is often compromised due to the hypopermeable and hypoxic characteristics… read more here.
Keywords: tumor; penetration; solid tumor; large solid ... See more keywords