Domino [Pd]-Catalysis: Heck followed by decarboxylative Sonogashira couplings under microwave irradiation in aqueous medium
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2019.03.015
Abstract: Abstract A copper free [Pd]-catalyzed domino intramolecular Heck and intermolecular decarboxylative Sonogashira couplings, for the synthesis of alkyne bearing heterocyclic compounds with a quaternary carbon atom, is described. Notably, this dual bond forming strategy is… read more here.
Keywords: heck; sonogashira couplings; decarboxylative sonogashira; domino ... See more keywords
Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03621
Abstract: Complexation of ca. 1000 ppm Pd(OAc)2 with the ligand HandaPhos (1-1.5:1) leads to a precatalyst that efficiently mediates Sonogashira couplings in aqueous nanomicelles under very mild conditions. Neither copper nor organic solvent is required in… read more here.
Keywords: sustainable handaphos; mild conditions; copper; handaphos ppm ... See more keywords