Combinations of nanovesicles and physical methods for enhanced transdermal delivery of a model hydrophilic drug
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.03.008
Abstract: Graphical abstract Figure. No caption available. &NA; Here, we combined lipid nanovesicles (ethosomes, liposomes) as the drug carrier systems with two physical methods (electroporation, sonoporation) to enhance transdermal delivery of a hydrophilic model molecule, calcein.… read more here.
Keywords: transdermal delivery; delivery; sonoporation; physical methods ... See more keywords
Monitoring the effect of sonoporation on the cells using electrochemical approach.
Sign Up to like & getrecommendations! Published in 2018 at "Ultrasonics sonochemistry"
DOI: 10.1016/j.ultsonch.2017.10.030
Abstract: Sonoporation is applied to enhance the permeability of the cell to bioactive materials by employing the acoustic cavitation of microbubbles. This phenomena would be helpful in molecular biology, delivery of large molecules into the cells… read more here.
Keywords: microscopy; effect sonoporation; sonoporation; sonoporation cells ... See more keywords
New insights on the role of ROS in the mechanisms of sonoporation-mediated gene delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Ultrasonics sonochemistry"
DOI: 10.1016/j.ultsonch.2020.104998
Abstract: Reactive oxygen species (ROS) are hypothesized to play a role in the sonoporation mechanisms. Nevertheless, the acoustical phenomenon behind the ROS production as well as the exact mechanisms of ROS action involved in the increased… read more here.
Keywords: sonoporation; role ros; gene delivery; role ... See more keywords
Mechanisms underlying sonoporation: Interaction between microbubbles and cells.
Sign Up to like & getrecommendations! Published in 2020 at "Ultrasonics sonochemistry"
DOI: 10.1016/j.ultsonch.2020.105096
Abstract: The past several decades have witnessed great progress in "smart drug delivery", an advance technology that can deliver genes or drugs into specific locations of patients' body with enhanced delivery efficiency. Ultrasound-activated mechanical force induced… read more here.
Keywords: sonoporation interaction; interaction microbubbles; sonoporation; microbubbles cells ... See more keywords
Ultrasound-Responsive Polymeric Micelles for Sonoporation-Assisted Site-Specific Therapeutic Action.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b05469
Abstract: Targeting drug delivery remains a challenge in various disease treatment including cancer. The local drug deposit could be greatly enhanced by some external stimuli-responsive systems. Here we develop pluronic P123/F127 polymeric micelles (M) encapsulating curcumin… read more here.
Keywords: tumor; site specific; sonoporation; cur ... See more keywords
Sonoporation-based labeling of mesenchymal stem cells with polymeric MRI contrast agents for live-cell tracking
Sign Up to like & getrecommendations! Published in 2019 at "Polymer Journal"
DOI: 10.1038/s41428-019-0177-4
Abstract: AbstractCell transplantation has the potential to improve repair of injured tissue function; however, it is not clear how transplanted cells participate in functional recovery. We have recently succeeded in tracking millions of transplanted living cells… read more here.
Keywords: cell; contrast; sonoporation; stem cells ... See more keywords
Effect of molecular weight on sonoporation-mediated uptake in human cardiac cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Acoustical Society of America"
DOI: 10.1121/1.4989211
Abstract: Sonoporation of cells induced by ultrasound-driven microbubble cavitation has been utilized for intracellular delivery of molecular therapeutics. The molecular weight of therapeutic agents can vary significantly, with DNA plasmids often larger than 5 MDa, siRNAs… read more here.
Keywords: mediated uptake; sonoporation mediated; sonoporation; molecular weight ... See more keywords
Applications of Ultrasound-Mediated Gene Delivery in Regenerative Medicine
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9050190
Abstract: Research on the capability of non-viral gene delivery systems to induce tissue regeneration is a continued effort as the current use of viral vectors can present with significant limitations. Despite initially showing lower gene transfection… read more here.
Keywords: medicine; sonoporation; tissue regeneration; gene ... See more keywords
Enhanced Radiosensitization for Cancer Treatment with Gold Nanoparticles through Sonoporation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21218370
Abstract: We demonstrate the megavoltage (MV) radiosensitization of a human liver cancer line by combining gold-nanoparticle-encapsulated microbubbles (AuMBs) with ultrasound. Microbubbles-mediated sonoporation was administered for 5 min, at 2 h prior to applying radiotherapy. The intracellular… read more here.
Keywords: gold nanoparticles; sonoporation; gold; cancer ... See more keywords
Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911222
Abstract: Sonoporation is the process of transient pore formation in the cell membrane triggered by ultrasound (US). Numerous studies have provided us with firm evidence that sonoporation may assist cancer treatment through effective drug and gene… read more here.
Keywords: landscape cellular; sonoporation; induced sonoporation; cellular bioeffects ... See more keywords
Application of Direct Sonoporation from a Defined Surface Area of the Peritoneum: Evaluation of Transfection Characteristics in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics11050244
Abstract: In the present study, we developed a sonoporation system, namely “direct sonoporation”, for transfecting the peritoneum from a defined surface area to avoid systematic side effects. Here, the transfection characteristics are explained because there is… read more here.
Keywords: transfection; peritoneum; direct sonoporation; sonoporation ... See more keywords