Phytochemistry and biological properties of isoprenoid flavonoids from Sophora flavescens Ait.
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DOI: 10.1016/j.fitote.2020.104556
Abstract: Sophora flavescens Ait (Ku-Shen in Chinese) is a popular traditional Chinese herbal medicine in China for a long history. It shows significant pharmacological activities in the treatment of dysentery, eczema, fever, jaundice, vulvar swelling, gastrointestinal… read more here.
Keywords: isoprenoid flavonoids; phytochemistry biological; biological properties; sophora flavescens ... See more keywords
Effect of pH regulation mode on byproduct ethanol generated from the lactic acid fermentation of Sophora flavescens residues
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DOI: 10.1016/j.jclepro.2020.123536
Abstract: Abstract Sophora flavescens residues (SFRs) were used to efficiently produce lactic acid (LA) through simultaneous saccharification and fermentation (SSF). When the pH value was adjusted to 8.5 with NaOH every 12 h, the maximum LA concentration… read more here.
Keywords: flavescens residues; fermentation; byproduct ethanol; sophora flavescens ... See more keywords
Chemical constituents of Sophora flavescens Ait. and cytotoxic activities of two new compounds.
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DOI: 10.1080/14786419.2020.1765340
Abstract: A chemical investigation of Sophora flavescens Ait. identified 6 compounds. On the basis of spectroscopic data, they were determined to be flavonoids and their analogues, among which were two previously undescribed compounds, sophoflavanone G (1)… read more here.
Keywords: ait cytotoxic; chemical constituents; constituents sophora; sophora flavescens ... See more keywords
Sophoranone A and B: two new cytotoxic prenylated metabolites and their analogs from the root bark of Sophora flavescens.
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DOI: 10.1080/14786419.2021.1894562
Abstract: Sophora flavescens Ait. has been utilized as an anticarcinogen, antibacterial and insecticide. Two new prenylflavonoids, Sophoflavonoid A (1) and Sophoflavonoid B (2), together with four known analogues were isolated from the root bark of S.… read more here.
Keywords: two new; cytotoxic; sophora flavescens; root bark ... See more keywords
Bacteroid Development, Transcriptome, and Symbiotic Nitrogen-Fixing Comparison of Bradyrhizobium arachidis in Nodules of Peanut (Arachis hypogaea) and Medicinal Legume Sophora flavescens
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DOI: 10.1128/spectrum.01079-22
Abstract: Rhizobial differentiation into bacteroids in leguminous nodules attracts scientists to investigate its different aspects. The development of bacteroids in the nodule of the important oil crop peanut was first investigated and compared to the status… read more here.
Keywords: peanut; sophora flavescens; nitrogen; bradyrhizobium arachidis ... See more keywords
An Integrated Fecal Microbiome and Metabolomics in T2DM Rats Reveal Antidiabetes Effects from Host-Microbial Metabolic Axis of EtOAc Extract from Sophora flavescens
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/1805418
Abstract: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease. Sophora flavescens (S. flavescens), also named Kushen, is a famous Chinese herbal medicine that has been used to prevent and cure T2DM both in folk… read more here.
Keywords: medicine; t2dm; metabolism; analysis ... See more keywords
Diversity patterns of soil microbial communities in the Sophora flavescens rhizosphere in response to continuous monocropping
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DOI: 10.1186/s12866-020-01956-8
Abstract: Background Continuous monocropping can affect the physicochemical and biological characteristics of cultivated soil. Sophora flavescens is a valuable herbal medicine and sensitive to continuous monocropping. Currently, diversity patterns of soil microbial communities in soil continuous… read more here.
Keywords: diversity; community; soil; microbial communities ... See more keywords
Simulation analysis and physiological and biochemical evaluation of Sophora flavescens aboveground against aphids using network pharmacology.
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DOI: 10.2139/ssrn.4174743
Abstract: Pests cause substantial damage to human environments; therefore, studying insecticidal mechanisms is crucial for improving pest control. However, the use of chemical pesticides can cause irreversible secondary damage. In this study, we used network pharmacology… read more here.
Keywords: pharmacology; network pharmacology; sophora flavescens; pest control ... See more keywords
Mechanisms of Compound Sophora flavescens (Kushen) Decoction for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking Technology.
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DOI: 10.2174/1573409918666220406103708
Abstract: BACKGROUND The Compound Sophora flavescenes (Kushen) Decoction was found to reduce the inflammatory symptom of Ulcerative colitis (UC). However, there exists a very limited understanding of the molecular pharmacological mechanisms. OBJECTIVE To explore the mechanism… read more here.
Keywords: pharmacology; compound sophora; flavescens kushen; sophora flavescens ... See more keywords
Taxonomic Structure of Rhizosphere Bacterial Communities and Its Association With the Accumulation of Alkaloidal Metabolites in Sophora flavescens
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DOI: 10.3389/fmicb.2021.781316
Abstract: Plant secondary metabolites (SMs) play a crucial role in plant defense against pathogens and adaptation to environmental stresses, some of which are produced from medicinal plants and are the material basis of clinical efficacy and… read more here.
Keywords: sophora flavescens; accumulation; rhizosphere bacterial; plant ... See more keywords
Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116104
Abstract: Sophoraflavanone G (SG), isolated from Sophora flavescens, has anti-inflammatory and anti-tumor bioactive properties. We previously showed that SG promotes apoptosis in human breast cancer cells and leukemia cells and reduces the inflammatory response in lipopolysaccharide-stimulated… read more here.
Keywords: oxidative stress; asthma; airway inflammation; response ... See more keywords