Planning Adjuvant Trials When Regimens Effective for Patients With Advanced Disease Don't Work in the Adjuvant Setting-Paradigms Lost.
Sign Up to like & getrecommendations! Published in 2017 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2017.0066
Abstract: Clinical benefit of a treatment demonstrated in patients with metastatic cancer leads to an optimistic and, understandably, logical belief that the same treatment is likely to be active against those apparently quiescent malignant cells that… read more here.
Keywords: adjuvant treatment; treatment; sorafenib; patients prescribed ... See more keywords
KIAA1429 mediates epithelial mesenchymal transition in sorafenib‐resistant hepatocellular carcinoma through m6A methylation modification
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5432
Abstract: Hepatocellular carcinoma (HCC) is a primary liver cancer with high mortality. The long‐term use of sorafenib, a targeted drug for hepatocellular carcinoma, will lead to drug resistance, and patients are prone to cancer metastasis, the… read more here.
Keywords: hepatocellular carcinoma; mediates epithelial; sorafenib; epithelial mesenchymal ... See more keywords
Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30989
Abstract: The survival benefit of sorafenib for hepatocellular carcinoma (HCC) patients is unsatisfactory due to the development of adaptive resistance. Increasing evidence has demonstrated that drug resistance can be acquired by cancer cells by activating a… read more here.
Keywords: hepatocellular carcinoma; combination; shp2; sorafenib ... See more keywords
Antitumor effect of sorafenib and mammalian target of rapamycin inhibitor in liver transplantation recipients with hepatocellular carcinoma recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Liver Transplantation"
DOI: 10.1002/lt.25191
Abstract: Both sorafenib and mammalian target of rapamycin inhibitor (mTORi) have antitumor effects. This study aimed to evaluate their antitumor effects in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) recurrence. We performed a laboratory study… read more here.
Keywords: administration; recurrence; study; sorafenib ... See more keywords
Activation of EGFR‐KLF4 positive feedback loop results in acquired resistance to sorafenib in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23102
Abstract: Sorafenib is the standard first‐line systemic chemotherapeutic drugs for advanced hepatocellular carcinoma (HCC), but acquired resistance to sorafenib is frequently observed in clinical practice. In this study, we first produced three sorafenib resistance (SR) HCC… read more here.
Keywords: positive feedback; hcc; feedback loop; sorafenib ... See more keywords
Non-invasive monitoring of the therapeutic response in sorafenib-treated hepatocellular carcinoma based on photoacoustic imaging
Sign Up to like & getrecommendations! Published in 2017 at "European Radiology"
DOI: 10.1007/s00330-017-4960-3
Abstract: AbstractPurposeWe investigated the changes of tissue oxygen saturation (sO2) in sorafenib-treated HCC (hepatocelluar carcinoma) mouse models using photoacoustic imaging (PI).Materials and MethodsNude mice, implanted with human HCC (HepG2-RFP) cells in the liver, were randomised to… read more here.
Keywords: sorafenib treated; hcc; sorafenib; non invasive ... See more keywords
Treatment efficacy by hepatic arterial infusion chemotherapy vs. sorafenib after liver-directed concurrent chemoradiotherapy for advanced hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03632-4
Abstract: We compared the clinical efficacies of hepatic arterial infusion chemotherapy (HAIC) vs. sorafenib as sequential maintenance therapy following liver-directed concurrent chemoradiotherapy (LD-CCRT) for locally advanced-stage hepatocellular carcinoma (HCC). Patients undergoing HAIC with 5-fluorouracil and cisplatin… read more here.
Keywords: hepatic arterial; infusion chemotherapy; treatment; sorafenib ... See more keywords
Effect of early adverse events resulting in sorafenib dose adjustments on survival outcomes of advanced hepatocellular carcinoma patients
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-020-01698-7
Abstract: Background Sorafenib is a current first-line treatment option for advanced hepatocellular carcinoma (HCC). This study aimed to evaluate the impact of early adverse events (AEs) requiring sorafenib dose adjustment on survival outcomes of patients with… read more here.
Keywords: hepatocellular carcinoma; survival outcomes; sorafenib; sorafenib dose ... See more keywords
Cyclodextrin polymers as nanocarriers for sorafenib
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DOI: 10.1007/s10637-017-0538-9
Abstract: SummaryPolymeric nanoparticles based on cyclodextrins are currently undergoing clinical trials as new promising nanotherapeutics. In light of this interest, we investigated cyclodextrin cross-linked polymers with different lengths as carriers for the poorly water-soluble drug sorafenib.… read more here.
Keywords: nanocarriers sorafenib; cyclodextrin polymers; sorafenib; polymers nanocarriers ... See more keywords
A phase I trial of concurrent sorafenib and stereotactic radiosurgery for patients with brain metastases
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DOI: 10.1007/s11060-017-2455-3
Abstract: We hypothesized that sorafenib (BAY 43-9006), an oral multi-kinase inhibitor, used in combination with SRS will improve overall intracranial control. This Phase I study assesses the safety, tolerability, and maximal tolerated dose of sorafenib administered… read more here.
Keywords: brain metastases; concurrent sorafenib; srs; sorafenib ... See more keywords
Sorafenib-Induced Acute Pancreatitis: Case Report and Review of the Literature
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-017-9980-3
Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is the third leading cause of cancer-related death worldwide [1]. The reported annual incidence of HCC is rising in most countries, mostly due to… read more here.
Keywords: acute pancreatitis; hcc; treatment; sorafenib ... See more keywords