Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Drug Delivery"
DOI: 10.1080/10717544.2018.1561766
Abstract: Abstract Background: To prepare sorafenib-loaded folate-decorated bovine serum nanoparticles (FA-SRF-BSANPs) and investigate their effect on the tumor targeting. Methods: The nanoparticles were characterized and evaluated by in vivo and in vitro experiments. Results: SRF-loaded BSA… read more here.
Keywords: srf bsanps; drug; loaded folate; sorafenib loaded ... See more keywords
Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02214-y
Abstract: Multidrug resistance (MDR) is a key determinant for hepatocellular carcinoma chemotherapy failure. P-glycoprotein is one of the main causes of MDR by causing drug efflux in tumor cells. In order to solve this thorny problem,… read more here.
Keywords: hepatocellular carcinoma; sorafenib loaded; multidrug resistance; tpgs ... See more keywords
Hybrid Lipid Nanoformulations for Hepatoma Therapy: Sorafenib Loaded Nanoliposomes—A Preliminary Study
Sign Up to like & getrecommendations! Published in 2022 at "Nanomaterials"
DOI: 10.3390/nano12162833
Abstract: Sorafenib is a multikinase inhibitor that has received increasing attention due to its high efficacy in hepatocellular carcinoma treatment. However, its poor pharmacokinetic properties (limited water solubility, rapid elimination, and metabolism) still represent major bottlenecks… read more here.
Keywords: nanoformulations hepatoma; sorafenib loaded; loaded nanoliposomes; hybrid lipid ... See more keywords