Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats
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DOI: 10.3390/pharmaceutics13122172
Abstract: A combination of the tyrosine kinase inhibitor—sorafenib—and the opioid analgesic—morphine—can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration… read more here.
Keywords: pharmacokinetic drug; sorafenib morphine; morphine; study ... See more keywords