Comprehensive network analysis of the molecular mechanisms associated with sorafenib resistance in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2020.04.076
Abstract: OBJECTIVE Hepatocellular carcinoma (HCC) is an intractable disease because patients with HCC frequently develop sorafenib resistance after long-term chemotherapy. Although studies has demonstrated the availability of cumulative information on drug-resistant patients, little is known about… read more here.
Keywords: hcc; analysis; drug; resistance ... See more keywords
Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.06.015
Abstract: BACKGROUND & AIMS We investigated the functional role and clinical significance of stearoyl-CoA desaturase-1 (SCD1) mediated endoplasmic reticulum (ER) stress in regulating liver tumor-initiating cells (T-ICs) and sorafenib resistance, with the aim of developing a… read more here.
Keywords: scd1; liver ics; stress; sorafenib resistance ... See more keywords
ETS‐1 induces Sorafenib‐resistance in hepatocellular carcinoma cells via regulating transcription factor activity of PXR
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.08.003
Abstract: ABSTRACT Transcription factor E26 transformation specific sequence 1 (ETS‐1) is a primary regulator in the metastasis of human cancer cells, especially hepatocellular carcinoma (HCC) cells; and it would affect the prognosis of HCC patients who… read more here.
Keywords: transcription factor; resistance; hcc; sorafenib resistance ... See more keywords
CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104800
Abstract: The HBV-initiated hepatocellular carcinoma (HCC) frequently develops from or accompanies long-term chronic hepatitis, inflammation, and cirrhosis, and has a poor prognosis. Sorafenib, an orally active multi-kinase inhibitor, currently the most common approved drug for first-line… read more here.
Keywords: hepatocellular carcinoma; ccl22 signaling; ccl22; sorafenib resistance ... See more keywords
New frontiers against sorafenib resistance in renal cell carcinoma: from molecular mechanisms to predictive biomarkers.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105732
Abstract: Renal cell carcinoma (RCC) is a highly vascularized tumor and prone to distant metastasis. Sorafenib is the first targeted multikinase inhibitor and first-line chemical drug approved for RCC therapy. In fact, only a small number… read more here.
Keywords: renal cell; cell carcinoma; resistance; sorafenib resistance ... See more keywords
CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00375-5
Abstract: Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the mechanisms underlying resistance have not been fully clarified. Here we report that a circular… read more here.
Keywords: circrna sore; resistance; hcc; sorafenib resistance ... See more keywords
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0187-x
Abstract: Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC), sorafenib is currently an effective first-line therapy. Unfortunately, the development of drug resistance to… read more here.
Keywords: hepatocellular carcinoma; mechanisms sorafenib; resistance; sorafenib resistance ... See more keywords
Long intergenic non-protein coding RNA 1273 confers sorafenib resistance in hepatocellular carcinoma via regulation of methyltransferase 3
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2025701
Abstract: ABSTRACT Hepatocellular carcinoma (HCC) is often diagnosed in patients with advanced disease who are ineligible for curative surgical therapies. Sorafenib is a first-line agent approved for the treatment of advanced HCC. However, the frequent resistance… read more here.
Keywords: hepatocellular carcinoma; hcc; long intergenic; resistance ... See more keywords
KDM5B regulates the PTEN/PI3K/Akt pathway to increase sorafenib-resistance in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001329
Abstract: Lysine-specific demethylase 5B (KDM5B) exerts its tumor-promoting functions in numerous malignancies, although the possible mechanisms by which KDM5B promotes cancer aggressiveness in hepatocellular carcinoma (HCC) have been preliminarily explored, the role of this gene in… read more here.
Keywords: kdm5b; pi3k akt; hcc; akt pathway ... See more keywords
ACTR confers to Sorafenib resistance in hepatocellular carcinoma via facilitating the Warburg effect.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer science"
DOI: 10.1111/cas.14412
Abstract: Sorafenib resistance is a major challenge in the therapy for advanced hepatocellular carcinoma (HCC)1 . However, the underlying molecular mechanism of HCC resistance to sorafenib remains unclear. Activator of thyroid and retinoid receptor (ACTR, also known as… read more here.
Keywords: hcc; actr; warburg effect; resistance ... See more keywords
Inflammatory microenvironment of fibrotic liver promotes hepatocellular carcinoma growth, metastasis and sorafenib resistance through STAT3 activation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16256
Abstract: The pro‐inflammatory and pro‐fibrotic liver microenvironment facilitates hepatocarcinogenesis. However, the effects and mechanisms by which the hepatic fibroinflammatory microenvironment modulates intrahepatic hepatocellular carcinoma (HCC) progression and its response to systematic therapy remain largely unexplored. We… read more here.
Keywords: microenvironment; hcc; liver; sorafenib resistance ... See more keywords