Investigation of sorafenib tosylate loaded liposomal dry powder inhaler for the treatment of non-small cell lung cancer
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DOI: 10.1080/02726351.2021.1906367
Abstract: Abstract The present hypothesis was to identify the potential of sorafenib tosylate (ST) loaded liposomal dry powder inhaler (ST-LDPI) for targeting non-small cell lung cancer (NSCLC). ST-LDPI was obtained by spray drying the ST loaded… read more here.
Keywords: sorafenib tosylate; dry powder; powder inhaler; tosylate loaded ... See more keywords
Formulating Ternary Inclusion Complex of Sorafenib Tosylate Using β-Cyclodextrin and Hydrophilic Polymers: Physicochemical Characterization and In Vitro Assessment
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DOI: 10.1208/s12249-022-02406-6
Abstract: Sorafenib tosylate (SFNT) is the first-line drug for hepatocellular carcinoma. It exhibits poor solubility leading to low oral bioavailability subsequently requiring intake of large quantities of drug to exhibit desired efficacy. The present investigation was… read more here.
Keywords: ternary inclusion; inclusion complex; sorafenib tosylate; inclusion ... See more keywords
Crystal Structure, Stability and Desolvation of the Solvates of Sorafenib Tosylate
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DOI: 10.3390/cryst9070367
Abstract: In this study, three solvates of sorafenib tosylate were obtained from methanol, ethanol and n-methyl-2-pyrrolidone (NMP) after solvate screening and the effect of solvent on the formation of solvate was analyzed. The solvents with high… read more here.
Keywords: sorafenib tosylate; desolvation solvates; solvates sorafenib; stability ... See more keywords