Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition
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DOI: 10.1093/cvr/cvaf021
Abstract: Abstract Aims In this study, we aimed to uncover genes associated with stressed cardiomyocytes by combining single-cell transcriptomic data sets from failing cardiac tissue from both humans and mice. Methods and results Our bioinformatic analysis… read more here.
Keywords: failure; integrin interactions; expression; sorbs2 ... See more keywords
Sorbs2 Is Required For Learning And Memory In Murine Excitatory Neurons
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DOI: 10.1152/physiol.2025.40.s1.1740
Abstract: Sorbs2 is a cytoskeletal adaptor protein expressed in hippocampal neurons; however, its mechanistic role in these cells remains understudied. A genetic variant in the Sorbs2 promoter is linked to increased Sorbs2 expression and an 11-year… read more here.
Keywords: role; physiology; stability; sorbs2 ... See more keywords
Sorbs2 mediates phenotypic plasticity and mechanotransduction in vascular smooth muscle cells
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DOI: 10.1152/physiol.2025.40.s1.1790
Abstract: Objective: Sorbs2 has previously been identified as a protein highly expressed in vascular tissues relative to other tissue types. Our goal is to understand the role of Sorbs2 in vascular biology. Hypothesis: Sorbs2 regulates the… read more here.
Keywords: phenotypic plasticity; vascular smooth; physiology; smooth muscle ... See more keywords
Abstract 4369381: Regulation of Nav1.5 Channel Surface Expression and Function by Sorbs2 in Atrial Cardiomyocytes
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DOI: 10.1161/circ.152.suppl_3.4369381
Abstract: Background: Voltage-gated Nav1.5 channel, encoded by SCN5A , is essential for initiation and propagation of action potentials (AP) in atria. Nav1.5 channelopathy is strongly associated with arrhythmogenesis, including atrial fibrillation. Sorbin and SH3 domain-containing protein… read more here.
Keywords: atrial cardiomyocytes; nav1 channel; sorbs2; expression function ... See more keywords
Abstract P2010: Cardiomyocyte Knockout Of Sorbs2 Rewires Cytoskeleton And Causes Dilated Cardiomyopathy
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DOI: 10.1161/res.131.suppl_1.p2010
Abstract: Sorbs2 is a cardiomyocyte-enriched, cytoskeletal adaptor protein and there is growing interest in understanding its roles in cardiac biology and disease. While Sorbs2 global knockout mice display lethal cardiomyopathy with severe arrhythmias, the underlying mechanisms… read more here.
Keywords: cardiomyocyte; knockout; sorbs2 cko; sorbs2 ... See more keywords
Genetic Analysis of TB Susceptibility Variants in Ghana Reveals Candidate Protective Loci in SORBS2 and SCL11A1 Genes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.729737
Abstract: Despite advancements made toward diagnostics, tuberculosis caused by Mycobacterium africanum (Maf) and Mycobacterium tuberculosis sensu stricto (Mtbss) remains a major public health issue. Human host factors are key players in tuberculosis (TB) outcomes and treatment.… read more here.
Keywords: analysis susceptibility; susceptibility variants; analysis; sorbs2 ... See more keywords