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   Articles with "sorla" as a keyword



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Exploring the sortilin related receptor, SorLA, in depression.

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recommendations! Published in 2018 at "Journal of affective disorders"

DOI: 10.1016/j.jad.2018.02.050

Abstract: BACKGROUND Studies of individual biomarkers for depression have shown insufficient sensitivity and specificity for clinical use, and most likely combinations of biomarkers may provide a better signature. The sorting-related receptor with A-type repeats (SorLA) is… read more here.

Keywords: depression; sorla; sorla levels; depressed individuals ... See more keywords
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A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance

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recommendations! Published in 2021 at "Oncogene"

DOI: 10.1038/s41388-020-01604-5

Abstract: Current evidence indicates that resistance to the tyrosine kinase-type cell surface receptor (HER2)-targeted therapies is frequently associated with HER3 and active signaling via HER2-HER3 dimers, particularly in the context of breast cancer. Thus, understanding the… read more here.

Keywords: sorla; response; her2; resistance ... See more keywords
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Strong Correlation of Genome-Wide Expression after Traumatic Brain Injury In Vitro and In Vivo Implicates a Role for SORLA.

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recommendations! Published in 2017 at "Journal of neurotrauma"

DOI: 10.1089/neu.2015.4306

Abstract: The utility of in vitro models of traumatic brain injury (TBI) depends on their ability to recapitulate the in vivo TBI cascade. In this study, we used a genome-wide approach to compare changes in gene… read more here.

Keywords: sorla; model; expression; vitro ... See more keywords
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SorLA in Interleukin-6 Signaling and Turnover

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recommendations! Published in 2017 at "Molecular and Cellular Biology"

DOI: 10.1128/mcb.00641-16

Abstract: ABSTRACT Interleukin-6 (IL-6) is a multifunctional cytokine with important functions in various physiologic processes. Mice lacking IL-6 exhibit multiple phenotypic abnormalities, such as an inadequate immune and acute-phase response, and elevated levels of circulating IL-6… read more here.

Keywords: signaling turnover; sorla; biology; interleukin signaling ... See more keywords