A Cell-based Screen in Actinomyces oris to Identify Sortase Inhibitors
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DOI: 10.1038/s41598-020-65256-x
Abstract: Sortase enzymes are attractive antivirulence drug targets that attach virulence factors to the surface of Staphylococcus aureus and other medically significant bacterial pathogens. Prior efforts to discover a useful sortase inhibitor have relied upon an… read more here.
Keywords: sortase inhibitors; screen actinomyces; cell based; based screen ... See more keywords
Formulation and Biological Evaluation of Mesoporous Silica Nanoparticles Loaded with Combinations of Sortase A Inhibitors and Antimicrobial Peptides
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DOI: 10.3390/pharmaceutics14050986
Abstract: This study aimed to develop synergistic therapies to treat superbug infections through the encapsulation of sortase A inhibitors (SrtAIs; trans-chalcone (TC), curcumin (CUR), quercetin (QC), or berberine chloride (BR)) into MCM-41 mesoporous silica nanoparticles (MSNs)… read more here.
Keywords: mcm po3; silica nanoparticles; mesoporous silica; sortase inhibitors ... See more keywords