Development of a Cell-Based Assay to Assess Binding of the proNGF Prodomain to Sortilin
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0558-1
Abstract: Sortilin was first identified based on its activity as part of intracellular protein sorting machinery. Recently, it was discovered that sortilin also acts as a cell surface receptor for the propeptide form of nerve growth… read more here.
Keywords: sortilin; cell based; interaction; based assay ... See more keywords
Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0806-x
Abstract: The amyloid precursor protein (APP), one key player in Alzheimer’s disease (AD), is extensively processed by different proteases. This leads to the generation of diverging fragments including the amyloid β (Aβ) peptide, which accumulates in… read more here.
Keywords: transmembrane proteins; alzheimer disease; sortilin; sortilin calsyntenin ... See more keywords
Maternal serum Sortilin-1 level as a potential biomarker for intrahepatic cholestasis of pregnancy
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2119957
Abstract: Abstract Objective: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease related to pregnancy in women. Sortilin-1 is a sorting receptor belonging to the vacuolar protein sorting 10 (Vps10p) domain family, and recent… read more here.
Keywords: serum sortilin; maternal serum; pregnancy; sortilin ... See more keywords
Overexpression of sortilin is associated with 5‐FU resistance and poor prognosis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15752
Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide. Even if 5‐fluorouracil (5‐FU) is used as the first‐line chemotherapeutic drug, responsiveness is only 20‐30%. Acquired resistance to 5‐FU contributes to both poor patient prognosis… read more here.
Keywords: overexpression; prognosis; sortilin; resistance ... See more keywords
Serum sortilin as a predictor of stroke in patients with intermediate carotid artery stenosis.
Sign Up to like & getrecommendations! Published in 2022 at "Vascular"
DOI: 10.1177/17085381211067051
Abstract: BACKGROUND Sortilin was an important molecular protein involved in the pathogenesis of atherosclerosis. Besides, serum sortilin was associated with adverse cerebrovascular events. Atherosclerotic stenosis in the carotid artery is a major etiology for ischemic stroke.… read more here.
Keywords: carotid artery; stroke patients; serum sortilin; sortilin ... See more keywords
The association of plasma sortilin with essential hypertension and subclinical carotid atherosclerosis: A cross-sectional study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.966890
Abstract: Background Sortilin, a protein that regulates glucose and lipid metabolism, has recently been linked to cardiovascular diseases (CVDs) such as coronary heart disease and carotid artery stenosis. In this study, we measured circulating sortilin concentrations… read more here.
Keywords: carotid atherosclerosis; carotid; subclinical carotid; plasma sortilin ... See more keywords
Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.856734
Abstract: Peripheral nerve regeneration relies on the ability of Schwann cells to support the regrowth of damaged axons. Schwann cells re-differentiate when reestablishing contact with the sprouting axons, with large fibers becoming remyelinated and small nociceptive… read more here.
Keywords: regeneration; remak bundle; schwann cell; remak ... See more keywords
Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin
Sign Up to like & getrecommendations! Published in 2020 at "Biomedicines"
DOI: 10.3390/biomedicines8110450
Abstract: Schwann cells (SCs) are the main glial cells of the peripheral nervous system (PNS) and are known to be involved in various pathophysiological processes, such as diabetic neuropathy and nerve regeneration, through neurotrophin signaling. Such… read more here.
Keywords: neurotrophin receptor; receptor sortilin; sortilin; p75 neurotrophin ... See more keywords
Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.266916
Abstract: Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases. However, the pathogenesis underlying long-term adenosine A1 receptor activation-induced neurodegeneration remains unclear. In this study, rats… read more here.
Keywords: adenosine receptor; sortilin; expression; activation ... See more keywords