Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin
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DOI: 10.1007/s12035-017-0806-x
Abstract: The amyloid precursor protein (APP), one key player in Alzheimer’s disease (AD), is extensively processed by different proteases. This leads to the generation of diverging fragments including the amyloid β (Aβ) peptide, which accumulates in… read more here.
Keywords: transmembrane proteins; alzheimer disease; sortilin; sortilin calsyntenin ... See more keywords