Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
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DOI: 10.1038/s41467-017-00481-z
Abstract: Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular receptors to induce their internalization. While Nef-mediated CD4 downmodulation is conserved, the ability to internalize CD3 was lost in HIV-1 and its precursors.… read more here.
Keywords: cd3; nef mediated; motif interactions; sorting motif ... See more keywords