DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.04.043
Abstract: DNAJC13 (RME-8) is a core co-chaperone that facilitates membrane recycling and cargo sorting of endocytosed proteins. DNAJ/Hsp40 (heat shock protein 40) proteins are highly conserved throughout evolution and mediate the folding of nascent proteins, and… read more here.
Keywords: membrane dynamics; dnajc13 asn855ser; sorting nexin; parkinsonism ... See more keywords
A Comparative Analysis of the Membrane Binding and Remodeling Properties of Two Related Sorting Nexin Complexes Involved in Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00007
Abstract: The sorting nexin (SNX) proteins, Atg20 and Atg24, are involved in nonselective autophagy, are necessary for efficient selective autophagy, and are required for the cytoplasm-to-vacuole transport pathway. However, the specific roles of these proteins in… read more here.
Keywords: atg20 atg24; binding remodeling; remodeling properties; sorting nexin ... See more keywords
Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5463134
Abstract: Parkinson's disease (PD) is a common neurodegenerative disease in the elderly, which is related to brain iron metabolism disorders. Ferroptosis is a newly discovered iron-dependent programmed cell death mode, which has been considered an essential… read more here.
Keywords: disease; parkinson disease; sorting nexin; model ... See more keywords
Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.211672
Abstract: ABSTRACT The endo-lysosomal network serves an essential role in determining the fate of endocytosed transmembrane proteins and their associated proteins and lipids. Sorting nexins (SNXs) play a central role in the functional organisation of this… read more here.
Keywords: nexin scaffold; snx21; scaffold endosomal; biology ... See more keywords
The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0207205
Abstract: Sorting nexin 5 (SNX5), a member of sorting nexin family, plays an important role in membrane trafficking, including the retrograde trafficking of the cation independent mannose 6-phosphate receptor (CI-M6PR) and macropinocytosis. Using ESI-LCMS/MS analysis, we… read more here.
Keywords: snx1 snx2; macropinocytosis; sorting nexin; serine 226 ... See more keywords
The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201852
Abstract: Binding of sorting nexin SNX5 to the VAB domain of VPS13A mediates its recruitment to membrane contact sites between SNX5-containing endosomal membranes, mitochondria, and ER. Human VPS13 proteins are implicated in severe neurological diseases. These… read more here.
Keywords: nexin snx5; snx5; sorting nexin; vps13a ... See more keywords
Sorting nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.279636
Abstract: Germline defects affecting the DNA-binding domain of the transcription factor FLI1 are associated with a bleeding disorder that is characterized by the presence of large, fused α-granules in platelets. We investigated whether the genes showing… read more here.
Keywords: granule biogenesis; sorting nexin; required granule; expression ... See more keywords
The Essential Role of Sorting Nexin 5 in Virus-Induced Autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.947384
Abstract: Autophagy, a conserved lysosomal degradation pathway, can degrade intracellular waste, such as damaged organelles or misfolded proteins, to meet the metabolic needs of cells and maintain the homeostasis of the intracellular environment (1). In addition,… read more here.
Keywords: essential role; sorting nexin; induced autophagy; virus ... See more keywords