Mathematical modelling of nonlinear dynamics generated from modular interconnections in cellular SOS response system
Sign Up to like & getrecommendations! Published in 2018 at "Nonlinear Dynamics"
DOI: 10.1007/s11071-018-4215-0
Abstract: Nonlinear dynamics in synthetic biology systems, generated as a consequence of interconnections between biological modules, poses challenges to the objective of engineering biological systems with predictable characteristics. Mathematical models, that often provide accurate descriptions of… read more here.
Keywords: sos response; response system; biology; nonlinear dynamics ... See more keywords
p-Coumaric acid inhibits the Listeria monocytogenes RecA protein functions and SOS response: An antimicrobial target.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.093
Abstract: Bacterial RecA plays an important role in the evaluation of antibiotic resistance via stress-induced DNA repair mechanism; SOS response. Accordingly, RecA became an important therapeutic target against antimicrobial resistance. Small molecule inhibitors of RecA may… read more here.
Keywords: response; sos response; coumaric acid; resistance ... See more keywords
Quantitative proteomics reveals the molecular mechanism of Aeromonas hydrophila in enoxacin stress.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103561
Abstract: Aeromonas hydrophila is an aquatic pathogen that has been of increasing concern in cultivation fisheries because of antibiotics resistance; however, its intrinsic antibiotics resistance mechanism remains elusive. In this study, a label-free-based proteomics method was… read more here.
Keywords: mechanism; response; sos response; stress ... See more keywords
Structural basis for regulation of SOS response in bacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217493120
Abstract: In response to DNA damage, bacterial RecA protein forms filaments with the assistance of DinI protein. The RecA filaments stimulate the autocleavage of LexA, the repressor of more than 50 SOS genes, and activate the… read more here.
Keywords: sos response; filament groove; reca filaments; response bacteria ... See more keywords
Role of the SOS Response in the Generation of Antibiotic Resistance In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00013-21
Abstract: The SOS response to DNA damage is a conserved stress response in Gram-negative and Gram-positive bacteria. Although this pathway has been studied for years, its relevance is still not familiar to many working in the… read more here.
Keywords: response; resistance; sos response; vivo ... See more keywords
Zinc Acetate Potentiates the Action of Tosufloxacin against Escherichia coli Biofilm Persisters
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00069-19
Abstract: Formation of bacterial biofilms is a major health threat due to their high levels of tolerance to multiple antibiotics and the presence of persisters responsible for infection relapses. We previously showed that a combination of… read more here.
Keywords: zinc acetate; tolerance; sos response; biofilm ... See more keywords
Synergistic Effect of SOS Response and GATC Methylome Suppression on Antibiotic Stress Survival in Escherichia coli
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01392-22
Abstract: The suppression of the SOS response has been shown to enhance the in vitro activity of quinolones. Furthermore, Dam-dependent base methylation has an impact on susceptibility to other antimicrobials affecting DNA synthesis. ABSTRACT The suppression… read more here.
Keywords: sos response; methylation; reca; suppression ... See more keywords
Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0178303
Abstract: Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E. coli, the SOS… read more here.
Keywords: response; zinc; sos response; coli ... See more keywords
The Interaction of RecA With Both CheA and CheW Is Required for Chemotaxis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.00583
Abstract: Salmonella enterica is the most frequently reported cause of foodborne illness. As in other microorganisms, chemotaxis affords key physiological benefits, including enhanced access to growth substrates, but also plays an important role in infection and… read more here.
Keywords: chea chew; reca; sos response; formation ... See more keywords
The DNA Damage Inducible SOS Response Is a Key Player in the Generation of Bacterial Persister Cells and Population Wide Tolerance
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.01785
Abstract: Population-wide tolerance and persisters enable susceptible bacterial cells to endure hostile environments, including antimicrobial exposure. The SOS response can play a significant role in the generation of persister cells, population-wide tolerance, and shielding. The SOS… read more here.
Keywords: sos response; wide tolerance; population wide; response ... See more keywords
Resistance of Bacteria toward 475 nm Blue Light Exposure and the Possible Role of the SOS Response
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12101499
Abstract: The increase in antibiotic resistance represents a major global challenge for our health systems and calls for alternative treatment options, such as antimicrobial light-based therapies. Blue light has shown promising results regarding the inactivation of… read more here.
Keywords: sos response; 475 blue; blue light; reca ... See more keywords