Abstract B002: Development of bifunctional CRBN-SOS1 degraders for treatment of mutant KRAS cancers
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DOI: 10.1158/1557-3125.ras23-b002
Abstract: Although oncogenic Kirsten rat sarcoma virus (KRAS) was once deemed undruggable, recent advances have revealed promising anti-tumor effects with pan-KRAS and KRAS-mutant specific inhibitors in both preclinical and clinical settings. Despite the success of these… read more here.
Keywords: sos1; sos1 degraders; kras mutant; degradation ... See more keywords