Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1812963116
Abstract: Significance Mutants of RAS are major oncogenes and occur in many human cancers, but efforts to develop drugs that directly inhibit the corresponding constitutively active RAS proteins have failed so far. We therefore focused on… read more here.
Keywords: inhibitors block; sos1; interaction; sos1 interaction ... See more keywords
Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature.
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DOI: 10.1080/13543776.2021.1952984
Abstract: IntroductionUp to 30% of all human cancers are driven by the overactivation of RAS signaling. Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents… read more here.
Keywords: son sevenless; small molecule; sos1; sevenless sos1 ... See more keywords