Articles with "sos1 interaction" as a keyword



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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

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Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1812963116

Abstract: Significance Mutants of RAS are major oncogenes and occur in many human cancers, but efforts to develop drugs that directly inhibit the corresponding constitutively active RAS proteins have failed so far. We therefore focused on… read more here.

Keywords: inhibitors block; sos1; interaction; sos1 interaction ... See more keywords