Abstract 515: Discovery of potent and orally available small molecule inhibitors of the SOS1-KRAS interaction
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DOI: 10.1158/1538-7445.am2023-515
Abstract: Abnormal activating mutation of KRAS is frequently found in many human cancers, including pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), and non-small cell lung cancer (NSCLC). KRAS activating mutations lead to hyperactivation of the MAPK/ERK… read more here.
Keywords: interaction; orally available; discovery potent; sos1 kras ... See more keywords