Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers.
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DOI: 10.1021/acs.jmedchem.3c00075
Abstract: The linker moiety of a proteolysis-targeting chimera (PROTAC) molecule plays a critical role in modulating the degradation activity, target selectivity, and physico-chemical properties. However, the basics and underlying mechanisms of chemical modifications of the linker… read more here.
Keywords: selective sos1; kras mutant; sos1 protac; protac zz151 ... See more keywords