PO-173 Critical requirement of the Sos1 and Sos2 RasGEFs for maintenance of mitochondrial homeostasis
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DOI: 10.1136/esmoopen-2018-eacr25.695
Abstract: Introduction The homologous, ubiquitously expressed, members (Sos1 and Sos2) of the Sos family of RasGEFs participate in multiple signalling pathways but their specific cellular functions are not clearly defined yet. Material and methods Using a… read more here.
Keywords: sos1 dko; sos1 sos2; sos1; sos1 sos1 ... See more keywords
Targeting of SOS1: from SOS1 Activators to Proteolysis Targeting Chimeras.
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DOI: 10.2174/1381612829666230418114520
Abstract: The most frequent mutated oncogene KRAS in lung cancer is targeted by KRAS G12C-directed drugs, such as Sotorasib and Adagrasib. Still, other alleles frequently expressed in pancreatic and colon cancer may be attacked indirectly by… read more here.
Keywords: sos1 activators; targeting sos1; sos1; activators proteolysis ... See more keywords