Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.
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DOI: 10.1111/epi.17232
Abstract: OBJECTIVE The formation of 24S-hydroxycholesterol is a brain-specific mechanism of cholesterol catabolism catalysed by cholesterol 24-hydroxylase (CYP46A1 also known as CH24H). CH24H has been implicated in various biological mechanisms whereas pharmacological lowering of 24S-hydroxycholesterol has… read more here.
Keywords: 24s hydroxycholesterol; cholesterol; soticlestat novel; cholesterol hydroxylase ... See more keywords