Glycan and Protein Analysis of Glycoengineered Bacterial E. coli Vaccines by MALDI-in-Source Decay FT-ICR Mass Spectrometry
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DOI: 10.1021/acs.analchem.1c04690
Abstract: Bacterial glycoconjugate vaccines have a major role in preventing microbial infections. Immunogenic bacterial glycans, such as O-antigen polysaccharides, can be recombinantly expressed and combined with specific carrier proteins to produce effective vaccines. O-Antigen polysaccharides are… read more here.
Keywords: source decay; glycoconjugate vaccines; mass spectrometry; analysis ... See more keywords
Surface Effects of Iron Oxide Nanoparticles on the MALDI In-Source Decay Analysis of Glycans and Peptides
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DOI: 10.1021/acsanm.9b00988
Abstract: Inorganic nanoparticles as MALDI matrices have recently been explored to study the molecular mass determination and structural analysis of glycans and peptides. However, the specific factors contributing to the success of the analysis are not… read more here.
Keywords: analysis glycans; glycans peptides; source decay; nanoparticles maldi ... See more keywords
Experimental and Theoretical Investigation of MALDI In-Source Decay of Peptides with a Reducing Matrix: What Is the Initial Fragmentation Step?
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DOI: 10.1021/jasms.2c00066
Abstract: Matrix-assisted laser desorption/ionization in-source decay (MALDI-ISD) with a reducing matrix is believed to be initiated by hydrogen transfer from the matrix to the peptide. Several new matrices have recently been developed to achieve more efficient… read more here.
Keywords: fragmentation; source decay; reducing matrix; maldi isd ... See more keywords