Formation of the node of Ranvier by Schwann cells is under control of transcription factor Sox10
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.23973
Abstract: The transcription factor Sox10 is an essential regulator of genes that code for structural components of the myelin sheath and for lipid metabolic enzymes in both types of myelinating glia in the central and peripheral… read more here.
Keywords: transcription factor; sox10; node ranvier; factor sox10 ... See more keywords
SOX10 mutation causes Waardenburg syndrome associated with distinctive phenotypic features in an Iranian family: A clue for phenotype-directed genetic analysis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2017.03.016
Abstract: BACKGROUND Waardenburg syndrome (WS) is a neurocristopathy characterized by hearing impairment and pigmentary disturbances in hair, eyes, and skin. WS is clinically heterogeneous and can be subdivided into four major types (WS1-WS4) where WS4 or… read more here.
Keywords: waardenburg syndrome; distinctive phenotypic; directed genetic; sox10 ... See more keywords
Migration pathways of sacral neural crest during development of lower urogenital tract innervation.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.04.011
Abstract: The migration and fate of cranial and vagal neural crest-derived progenitor cells (NCPCs) have been extensively studied; however, much less is known about sacral NCPCs particularly in regard to their distribution in the urogenital system.… read more here.
Keywords: tract; migration; sox10; innervation ... See more keywords
EEF1A1 deacetylation enables transcriptional activation of remyelination
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17243-z
Abstract: Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively) is a prerequisite for functional recovery after lesion. However, this process is not always optimal and becomes inefficient in the course of multiple… read more here.
Keywords: remyelination; eef1a1 deacetylation; sox10; activation ... See more keywords
The Utility of SOX10 Immunohistochemical Staining in Breast Pathology.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac092
Abstract: OBJECTIVES SOX10 expression helps identify melanocytic lesions. Over time, novel uses have been identified, such as expression in triple-negative breast cancer (TNBC). We evaluated the usefulness of SOX10 in breast pathology-specifically, identification and subtyping of… read more here.
Keywords: sox10; expression; pathology; tnbc ... See more keywords
Abstract A56: A SOX10-associated epigenetic program linking primitive differentiation state with reduced immunogenicity in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-a56
Abstract: Triple-negative breast cancer (TNBC) is arguably the most heterogeneous breast cancer subtype, with diverse histologic features and clinical behavior, yet limited therapeutic options. TNBCs exhibit impressive early responses to chemotherapy, but this is not a… read more here.
Keywords: breast cancer; sox10; expression; differentiation ... See more keywords
Sox10 contributes to the balance of fate choice in dorsal root ganglion progenitors
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DOI: 10.1371/journal.pone.0172947
Abstract: The development of functional peripheral ganglia requires a balance of specification of both neuronal and glial components. In the developing dorsal root ganglia (DRGs), these components form from partially-restricted bipotent neuroglial precursors derived from the… read more here.
Keywords: specification; sensory neuron; dorsal root; fate ... See more keywords
SOX10 – A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s250867
Abstract: Introduction Differential diagnosis of metaplastic squamous cell carcinoma of breast (MSCCB) is difficult. In particular, in terms of metastatic MSCCB, because of the low speciality of traditional markers such as mammaglobin, gross cystic disease fluid… read more here.
Keywords: diagnosis; msccb; sox10; breast ... See more keywords