P01.26.B M6A-MEDIATED UPREGULATION OF SOX11 DRIVES CHROMATIN REMODELING AND STEMNESS, CONTRIBUTING TO THERAPEUTIC RESISTANCE IN H3 K27M-MUTANT SPINAL CORD GLIOMAS
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf193.106
Abstract: Spinal cord gliomas are rare intramedullary tumors (0.25-0.4/100,000 annually) with distinct molecular features compared to intracranial gliomas. H3 K27M-mutant spinal gliomas show strong stem-like traits and intrinsic resistance to therapy. Our preliminary data identified m6A… read more here.
Keywords: mutant spinal; resistance; sox11; therapeutic resistance ... See more keywords
SOX11, a key oncogenic factor in mantle cell lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000434
Abstract: Purpose of review SOX11 has emerged as a key transcription factor in the pathogenesis of mantle cell lymphoma (MCL) whereas it is not expressed in normal B cells or virtually in any other mature B-cell… read more here.
Keywords: mcl; mantle cell; sox11; factor ... See more keywords
Hypomethylation‐associated Sox11 upregulation promotes oncogenesis via the PI3K/AKT pathway in OLP‐associated OSCC
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18556
Abstract: Oral lichen planus (OLP) is a particularly prevalent oral disorder with the potential to progress to oral squamous cell carcinoma (OSCC). SRY‐box transcription factor 11 (Sox11) has been reported to serve as a prognostic marker… read more here.
Keywords: olp associated; sox11; akt pathway; associated oscc ... See more keywords
lncRNA CYTOR Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Modulating SOX11 via Sponging miR-6512-3p
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/5671809
Abstract: Periodontal ligament stem cells (PDLSCs) are considered ideal cell sources for the regeneration of periodontal and alveolar bone tissue. Cytoskeleton Regulator RNA (CYTOR), a newly discovered long noncoding RNA, has been reported to function as… read more here.
Keywords: pdlscs; osteogenic differentiation; cytor; mir 6512 ... See more keywords
SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma
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DOI: 10.1158/1078-0432.ccr-20-5039
Abstract: Purpose: Mantle cell lymphoma (MCL) is a fatal subtype of non–Hodgkin lymphoma. SOX11 transcription factor is overexpressed in the majority of nodal MCL. We have previously reported that B cell–specific overexpression of SOX11 promotes MCL… read more here.
Keywords: lymphoma sox11; cell lymphoma; mcl; sox11 inhibitors ... See more keywords
Abstract 921: SOX11-mediated antigen presentation suppression: A mechanism of immune evasion in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-921
Abstract: Triple-negative breast cancer (TNBC) is an aggressive subtype with no targeted therapies and limited response to immunotherapy. TNBC evades immune surveillance by repressing antigen presentation machinery (APM) genes, reducing MHC Class I expression. Using bioinformatics,… read more here.
Keywords: cancer; antigen presentation; sox11; expression ... See more keywords
Abstract A024: SOX11: An Achilles heel of mantle cell lymphoma enhancing sensitivity to DNA damaging agents by impairing DNA repair
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth24-a024
Abstract: Mantle cell lymphoma (MCL) is an aggressive malignancy with mature B-cell differentiation and a median overall survival of 5 years. A characteristic hallmark of MCL is the aberrant expression of the transcription factor sex determining… read more here.
Keywords: cell lymphoma; sox11; mantle cell; sensitivity ... See more keywords
Transcriptomic Analysis in Mantle Cell Lymphoma Patients Identified MALAT1 Long-Non-Coding RNA to Regulate Cell Cycle Progression By Modulating EZH2/p57/Sox11 Axis
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DOI: 10.1182/blood-2024-209941
Abstract: Introduction: Mantle Cell Lymphoma (MCL), a rare and incurable form of B-cell lymphoma, presents significant challenges in treatment, with limited median progression-free survival. MCL is characterized by the translocation t(11;14) leading to overexpression of the… read more here.
Keywords: mcl; cell cycle; sox11; cell ... See more keywords
9242 SOX11 mutations cause hypogonadotropic hypogonadism through both hypothalamic and pituitary level deficits
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.1669
Abstract: Abstract Disclosure: B. Sun: None. S. Stockman: None. M. Stamou: None. L. Plummer: None. K. Salnikov: None. D. Kotan: None. K. Topaloglu: None. S.B. Seminara: None. R. Balasubramanian: None. AbstractPurpose: Human SOX11 mutations cause Coffin-Siris… read more here.
Keywords: hypogonadotropic hypogonadism; rsvs; none; sox11 mutations ... See more keywords
Definition and Characterization of SOX11-Derived T Cell Epitopes towards Immunotherapy of Glioma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24031943
Abstract: The transcription factor SOX11 is a tumor-associated antigen with low expression in normal cells, but overexpression in glioblastoma (GBM). So far, conventional surgery, chemotherapy, and radiotherapy have not substantially improved the dismal prognosis of relapsed/refractory… read more here.
Keywords: cell; gbm; characterization sox11; immunotherapy ... See more keywords