Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14193
Abstract: Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high‐fat diet, with… read more here.
Keywords: fatty liver; cd36; transcription factor; sox2 ... See more keywords
LncRNA SOX2‐OT regulates AKT/ERK and SOX2/GLI‐1 expression, hinders therapy, and worsens clinical prognosis in malignant lung diseases
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DOI: 10.1002/1878-0261.12875
Abstract: The involvement of LncRNA SOX2‐overlapping transcript (SOX2‐OT), SOX2, and GLI‐1 transcription factors in cancer has been well documented. Nonetheless, it is still unknown whether co‐expressed SOX2‐OT/SOX2 or SOX2‐OT/SOX2/GLI‐1 axes are epigenetically/transcriptionally involved in terms of… read more here.
Keywords: sox2 gli; sox2 sox2; lncrna sox2; sox2 ... See more keywords
Evaluation of Sox2 binding affinities for distinct DNA patterns using steered molecular dynamics simulation
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12316
Abstract: Transcription factors (TFs) are gene expression regulators that bind to DNA in a sequence‐specific manner and determine the functional characteristics of the gene. It is worthwhile to study the unique characteristics of such specific TF‐binding… read more here.
Keywords: dna; molecular dynamics; distinct dna; steered molecular ... See more keywords
Simultaneous targeted inhibition of Sox2‐Oct4 transcription factors using decoy oligodeoxynucleotides to repress stemness properties in mouse embryonic stem cells
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DOI: 10.1002/cbin.10847
Abstract: Transcriptional master regulators like Sox2 and Oct4, which are expressed in various human tumors, have been shown to cause tumor growth promotion as well as epithelial dysplasia by means of interfering with progenitor cell differentiation.… read more here.
Keywords: cell; sox2; stem cells; decoy ... See more keywords
Interferon‐induced transmembrane protein 1‐mediated EGFR/SOX2 signaling axis is essential for progression of non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31926
Abstract: Emerging data indicate that interferon‐induced transmembrane protein 1 (IFITM1) plays an important role in many cancers. However, it remains unclear whether IFITM1 is functionally indispensable in nonsmall cell lung cancer (NSCLC). Here, using NSCLC cell… read more here.
Keywords: interferon induced; ifitm1; induced transmembrane; sox2 ... See more keywords
MZF1 and GABP Cooperate with Sox2 in Regulating the Expression of YAP1 in Cancer Cells
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DOI: 10.1002/stem.2705
Abstract: The transcription factor YAP1 is a major effector of the tumor suppressive Hippo signaling pathway and is also necessary to maintain pluripotency in embryonic stem cells. Elevated levels of YAP1 expression antagonize the tumor suppressive… read more here.
Keywords: yap1; yap1 expression; expression; sox2 ... See more keywords
Sox2 Expression Marks Castration‐Resistant Progenitor Cells in the Adult Murine Prostate
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DOI: 10.1002/stem.2987
Abstract: Identification of defined epithelial cell populations with progenitor properties is critical for understanding prostatic development and disease. Here, we demonstrate that Sox2 expression is enriched in the epithelial cells of the proximal prostate adjacent to… read more here.
Keywords: prostate; sox2 expression; castration; sox2 ... See more keywords
LncRNA promoted inflammatory response in ischemic heart failure through regulation of miR-455-3p/TRAF6 axis
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation Research"
DOI: 10.1007/s00011-020-01348-8
Abstract: Objectives Ischemic heart failure (IHF) is the most common cause of death globally. Growing evidence shows abnormal expression of long non-coding RNAs in heart failure patients. This study aims to investigate the effect of sex-determining… read more here.
Keywords: mir 455; inflammatory response; heart failure; sox2 ... See more keywords
Sodium selenite attenuates lung adenocarcinoma progression by repressing SOX2-mediated stemness
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DOI: 10.1007/s00280-018-3561-4
Abstract: PurposeSodium selenite (SS) has been widely reported to induce apoptosis in various cancer cell types. However, the underlying molecular mechanisms governing SS-mediated repression of lung cancer stem cells remain largely undefined.MethodsIn vitro assays of cell… read more here.
Keywords: lung adenocarcinoma; progression repressing; attenuates lung; sox2 ... See more keywords
OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts.
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DOI: 10.1016/j.celrep.2017.07.071
Abstract: SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs), but it is unclear if they function as transcriptional activators or as repressors. We… read more here.
Keywords: sox2 work; human fibroblasts; sox2 vp16; oct4 sox2 ... See more keywords
Ectopic Gastric and Intestinal Phenotypes, Neuroendocrine Cell Differentiation, and SOX2 Expression Correlated With Early Tumor Progression in Colorectal Laterally Spreading Tumors
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2016.09.009
Abstract: Micro‐Abstract We analyzed 105 colorectal laterally spreading tumors (LSTs) resected by endoscopic submucosal dissection and investigated clinicopathologic differences among LST subtypes to identify factors indicative of malignant transformation and invasion. Ectopic gastric and intestinal phenotypes,… read more here.
Keywords: tumor progression; tumor; ectopic gastric; sox2 ... See more keywords