CRISPR/Cas9-mediated gene editing on Sox2ot promoter leads to its truncated expression and does not influence neural tube closure and embryonic development in mice.
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DOI: 10.1016/j.bbrc.2021.08.029
Abstract: Sox2 overlapping transcript (Sox2ot) is a long non-coding RNA (lncRNA), which harbors one of the major regulators of pluripotency, the Sox2 gene, in its intronic region. Sox2ot is primarily expressed in the developing neuroepithelium. However,… read more here.
Keywords: sox2ot promoter; embryonic development; neural tube; tube closure ... See more keywords