MYC‐activated lncRNA HNF1A‐AS1 overexpression facilitates glioma progression via cooperating with miR‐32‐5p/SOX4 axis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3186
Abstract: Mounting literatures have revealed the crucial effects of long noncoding RNA (lncRNA) in various cancers, including glioma. HNF1A‐AS1, a novel lncRNA, is reported to modulate tumorigenesis and development of multiple cancers. However, the tumorigenic function… read more here.
Keywords: glioma; sox4; as1; hnf1a as1 ... See more keywords
Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29918
Abstract: Sox4 participates in the progression of embryo development and regulation of apoptosis in tumors. However, the effect and mechanism of Sox4 in myocardial infarction (MI) remains unclear. Therefore, we aimed at examining the role and… read more here.
Keywords: apoptosis; sox4; expression; bim ... See more keywords
De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2018.12.014
Abstract: SOX4, together with SOX11 and SOX12, forms group C of SRY-related (SOX) transcription factors. They play key roles, often in redundancy, in multiple developmental pathways, including neurogenesis and skeletogenesis. De novo SOX11 heterozygous mutations have… read more here.
Keywords: associated mild; sox4 variants; variants cause; sox4 ... See more keywords
SOX4-activated lncRNA MCM3AP-AS1 aggravates osteoarthritis progression by modulating miR-149-5p/Notch1 signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Cytokine"
DOI: 10.1016/j.cyto.2022.155805
Abstract: OBJECTIVE To clarify the expression and underlying network of long non-coding RNA (lncRNA) MCM3AP-AS1 in osteoarthritis (OA). METHODS Human articular cartilage samples, OA model rats and IL-1β-treated C28/I2 cells were used in this study. The… read more here.
Keywords: lncrna mcm3ap; as1; mir 149; sox4 ... See more keywords
A TGF-β-MTA1-SOX4-EZH2 signaling axis drives epithelial–mesenchymal transition in tumor metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1132-8
Abstract: MTA1, SOX4, EZH2, and TGF-β are all potent inducers of epithelial–mesenchymal transition (EMT) in cancer; however, the signaling relationship among these molecules in EMT is poorly understood. Here, we investigated the function of MTA1 in… read more here.
Keywords: sox4; mta1 sox4; tgf; cancer ... See more keywords
SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01397-0
Abstract: Brown adipose tissue (BAT) is critical for non-shivering thermogenesis making it a promising therapeutic strategy to combat obesity and metabolic disease. However, the regulatory mechanisms underlying brown fat formation remain incompletely understood. Here, we found… read more here.
Keywords: brown fat; bat; sox4; ebf2 ... See more keywords
HOTAIR mediates cisplatin resistance in nasopharyngeal carcinoma by regulating miR-106a-5p/SOX4 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2038429
Abstract: ABSTRACT This study explored the function and mechanisms of HOX transcript antisense RNA (HOTAIR) in the drug resistance of nasopharyngeal carcinoma (NPC). Quantitative PCR, Western blotting, MTT assay, flow cytometry, Transwell assay, and luciferase assay… read more here.
Keywords: resistance nasopharyngeal; mir 106a; expression; sox4 ... See more keywords
Expanding the Immunophenotypic Spectrum of Neoplastic and Reactive Plasmacytoid Dendritic Cells.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac174
Abstract: OBJECTIVES Targeted therapies for blastic plasmacytoid dendritic cell neoplasm (BPDCN) have presented a diagnostic dilemma for differentiating residual BPDCN from reactive plasmacytoid dendritic cells (pDCs) because these conditions have a similar immunoprofile, necessitating discovery of… read more here.
Keywords: reactive plasmacytoid; sox4; plasmacytoid dendritic; dendritic cells ... See more keywords
Consolidation of the clinical and genetic definition of a SOX4-related neurodevelopmental syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medical genetics"
DOI: 10.1136/jmedgenet-2021-108375
Abstract: BACKGROUND A neurodevelopmental syndrome was recently reported in four patients with SOX4 heterozygous missense variants in the high-mobility-group (HMG) DNA-binding domain. The present study aimed to consolidate clinical and genetic knowledge of this syndrome. METHODS… read more here.
Keywords: clinical genetic; neurodevelopmental syndrome; sox4; hmg domain ... See more keywords
Abstract 516: SOX4 dictates gastric cancer progression by modulating the tumor immune microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-516
Abstract: SOX4 upregulation is common in multiple tumors, yet its role in shaping the immune microenvironment of gastric adenocarcinoma (GAC) remains unclear. This study investigates the influence of SOX4 on GAC progression and immune modulation. Using… read more here.
Keywords: cancer; gac; progression; sox4 ... See more keywords
SOX4 enhances tumor progression and cisplatin resistance in orthotopic mouse xenograft model of head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-15024-9
Abstract: SRY-related high-mobility-group box gene 4 (SOX4) is overexpressed in various cancers and has been studied as a therapeutic target in multiple malignancies. Therefore, this study aims to investigate the role of SOX4 in cancer progression… read more here.
Keywords: orthotopic mouse; progression; sox4; cell ... See more keywords