SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
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DOI: 10.1038/s41416-018-0338-9
Abstract: BackgroundSex-determining region Y-box (SRY-box) containing gene 9 (SOX9) expression confers cancer stem cell features. However, SOX9 function in intrahepatic cholangiocarcinoma (iCCA) is unknown. This study investigated the effects and underlying mechanisms of SOX9 in iCCA.MethodsSOX9… read more here.
Keywords: icca; expression decreases; sox9 expression; intrahepatic cholangiocarcinoma ... See more keywords
FGF23 and SOX9 expression in haemophilic cartilage: In vitro studies of the effects of iron
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DOI: 10.1111/hae.14623
Abstract: Clarifying the links between iron and FGF23, SOX9 expression in chondrocytes would be helpful for comprehending articular cartilage degradation pathogenesis in blood‐induced arthritis and exploring new protective methods. read more here.
Keywords: iron fgf23; cartilage; expression haemophilic; sox9 expression ... See more keywords
Transient Sox9 Expression Facilitates Resistance to Androgen-Targeted Therapy in Prostate Cancer
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DOI: 10.1158/1078-0432.ccr-19-0098
Abstract: Purpose: Patients with metastatic prostate cancer are increasingly presenting with treatment-resistant, androgen receptor–negative/low (AR−/Low) tumors, with or without neuroendocrine characteristics, in processes attributed to tumor cell plasticity. This plasticity has been modeled by Rb1/p53 knockdown/knockout… read more here.
Keywords: prostate cancer; cancer; sox9 expression;
Association of SOX9 expression with sensitivity to CDK7 inhibition and overall survival in triple-negative breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.1065
Abstract: 1065 Background: Triple-negative breast cancer (TNBC) has been shown to display cyclin-dependent kinase 7 (CDK7)-dependent transcriptional addition and is sensitive to a CDK7 inhibitor THZ1. As tumor heterogeneity is well known, we sought to identify… read more here.
Keywords: expression; breast cancer; sensitivity; cell ... See more keywords
The Clinicopathological and Prognostic Significance of SOX9 Expression in Gastric Cancer: Meta-Analysis and TCGA Analysis
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DOI: 10.3389/fonc.2021.668946
Abstract: Background The clinicopathological and prognostic significance of SRY-box transcription factor 9 (SOX9) expression in gastric cancer (GC) patients is still controversial. Our aim is to investigate the clinicopathological and prognostic value of SOX9 expression in… read more here.
Keywords: analysis; sox9 expression; expression; significance ... See more keywords
Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma
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DOI: 10.3892/or.2018.6665
Abstract: Transcription factor SRY-box 9 (SOX9) is a key regulator of chondrocyte differentiation and sex determination, and it is also involved in the progression of various types of human cancer. However, its putative association with oral… read more here.
Keywords: carcinoma; oral squamous; sox9 expression; expression ... See more keywords