Fibronectin fragment inhibits xylosyltransferase-1 expression by regulating Sp1/Sp3- dependent transcription in articular chondrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.01.006
Abstract: OBJECTIVE We investigated the effects of 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) on xylosyltransferase-1 (XT-1), an essential anabolic enzyme that catalyzes the initial and rate-determining step in glycosaminoglycan chain synthesis, in human primary chondrocytes. METHODS… read more here.
Keywords: transcription; kda; fibronectin fragment; sp1 sp3 ... See more keywords
Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000495715
Abstract: Background/Aims: Targeting survivin, an anti-apoptotic protein and mitotic regulator, is considered as an effective therapeutic option for pancreatic cancer (PaCa). Tolfenamic acid (TA) showed anti-cancer activity in pre-clinical studies. A recent discovery demonstrated a copper(II)… read more here.
Keywords: growth; cell; pancreatic cancer; sp1 sp3 ... See more keywords
Specificity Proteins (Sp) and Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065164
Abstract: The specificity protein (Sp) transcription factors (TFs) Sp1, Sp2, Sp3 and Sp4 exhibit structural and functional similarities in cancer cells and extensive studies of Sp1 show that it is a negative prognostic factor for patients… read more here.
Keywords: cell; sp1 sp3; sp3 sp4; specificity ... See more keywords