SP140 regulates the expression of immune‐related genes associated with multiple sclerosis and other autoimmune diseases by NF‐&kgr;B inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy284
Abstract: &NA; SP140 locus has been associated with multiple sclerosis (MS) as well as other autoimmune diseases by genome‐wide association studies (GWAS). The causal variant of these associations (rs28445040‐T) alters the splicing of the SP140 gene… read more here.
Keywords: associated multiple; autoimmune diseases; kgr inhibition; multiple sclerosis ... See more keywords
The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential
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DOI: 10.3390/cimb45050269
Abstract: SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between SP140 single nucleotide polymorphisms (SNPs) and diverse autoimmune and inflammatory diseases, suggesting a possible pathogenic role for… read more here.
Keywords: cell; maturation; epigenetic reader; expression ... See more keywords