Rhodium-Catalyzed Selective C(sp2)-H Activation/Annulation of tert-Butyl Benzoyloxycarbamates with 1,3-Diynes: A One Step Access to Alkynylated Isocoumarins and Bis-Isocoumarins.
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DOI: 10.1021/acs.orglett.2c01901
Abstract: We report here a Rh(III) catalyzed regio- and stereoselective synthesis of alkynylated and bis-isocoumarin from 1,3-dialkyne. Exclusive one-pot formation of 3,3-bis-isocoumarin isomers has been achieved by eliminating several other possibilities. This is the first example… read more here.
Keywords: bis isocoumarin; selective sp2; rhodium catalyzed; sp2 activation ... See more keywords
Ruthenium-Catalyzed C(sp2)-H Activation Using Pyridine and Imidazopyridine as Directing Groups for Selective Silylation.
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DOI: 10.1021/acs.orglett.5c03934
Abstract: Ruthenium-catalyzed C(sp2)-H activation using pyridine and imidazopyridine directing groups enables direct ortho-silylation of 2-arylimidazoheterocycles with hydrosilanes as silylation reagents. This method achieves regioselective C(sp2)-H silylation without the need for preactivation, affording ortho-silylated arylimidazo[1,2-a]pyridines in high… read more here.
Keywords: using pyridine; catalyzed sp2; ruthenium catalyzed; sp2 activation ... See more keywords
Access to (E)-N′-benzylidene-N-(2-(phenylsulfonyl)ethyl)acetohydrazide via C(sp2)−H activation and reduction of (E)-N′-benzylideneacetohydrazide with (vinylsulfonyl)benzene
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DOI: 10.1177/17475198241275297
Abstract: A novel route for C(sp3)-N bond formation via C(sp2)−H activation/reduction by metal-free which uses (E)-N′-benzylideneacetohydrazide and (vinylsulfonyl)benzene to synthesize derivatives of (E)-N′-benzylidene-N-(2-(phenylsulfonyl)ethyl)acetohydrazide has been reported. This methodology features good functional group tolerance and convenient operation.… read more here.
Keywords: activation reduction; via sp2; benzylidene phenylsulfonyl; benzylideneacetohydrazide vinylsulfonyl ... See more keywords