Synthesis of Diverse γ-Lactams via Rh-Catalyzed C(sp2)-H Addition to Aliphatic Nitriles.
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DOI: 10.1021/acs.orglett.2c01867
Abstract: We herein report an unprecedented pathway to access γ-lactams using acetonitrile analogues as coupling partners without oxidants, ligands, and Lewis acids. The reaction undergoes Rh-catalyzed C(sp2)-H addition to carbon-bound nitriles with the aid of an… read more here.
Keywords: sp2 addition; lactams via; synthesis diverse; catalyzed sp2 ... See more keywords