Palladium-Catalyzed Access to Benzocyclobutenone-Derived Ketonitrones via C(sp2)–H Functionalization
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DOI: 10.1021/acs.orglett.2c01317
Abstract: The palladium-catalyzed C(sp2)–H functionalization of bromoaryl aldonitrones leading to benzocyclobutenone-derived ketonitrones is described. This method allows for the preparation of a wide range of strained, four-membered ketonitrones with broad functional group tolerance. Downstream transformations of… read more here.
Keywords: derived ketonitrones; benzocyclobutenone derived; palladium catalyzed; sp2 functionalization ... See more keywords
Tropone-Enabled Pd-Catalyzed C(sp2)-H Functionalization of Phenylalanine: Switchable Access to Indoline and Olefinate.
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DOI: 10.1021/acs.orglett.5c03211
Abstract: Herein, we report Pd-catalyzed and site-selective C(sp2)-H amination/olefination of phenylalanine. The transformation proceeds via a troponyl carbonyl-directed intramolecular C-N cyclization forming indoline scaffolds through C(sp2)-H activation with PIDA. In the absence of PIDA, ortho-C(sp2)-H olefination… read more here.
Keywords: enabled catalyzed; sp2; catalyzed sp2; phenylalanine ... See more keywords
Metal-Free Diaryl Etherification of Tertiary Amines by Ortho-C(sp2)-H Functionalization for Synthesis of Dibenzoxazepines and -ones.
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DOI: 10.1021/acs.orglett.7b03328
Abstract: A phenyliodine(III) diacetate mediated umpolung reactivity of the tertiary amines with suitably substituted o-hydroxybenzyl and phenyl groups is exploited to facilitate o-C(sp2)-H functionalization to afford diaryl ethers. The presence of an o-CHO and secondary amine… read more here.
Keywords: diaryl; sp2 functionalization; tertiary amines; synthesis dibenzoxazepines ... See more keywords
Rh(iii)-Catalyzed C(sp2)–H functionalization/cyclization cascade of N-carboxamide indole and iodonium reagents for access to indoloquinazolinone derivatives
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DOI: 10.1039/d1gc01820e
Abstract: The sustainable synthesis of indoloquinazolinone derivatives from N-methoxycarbamoyl indoles and iodonium ylide reagents in methanol is described. read more here.
Keywords: functionalization cyclization; catalyzed sp2; indoloquinazolinone derivatives; iii catalyzed ... See more keywords