Serine-/Cysteine-Based sp2-Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01948
Abstract: Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating the development of proinflammatory responses. Translating them to the clinical setting is hampered by synthetic difficulties, the lack… read more here.
Keywords: serine cysteine; iminoglycolipids novel; based sp2; cysteine based ... See more keywords
Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4379429
Abstract: The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound a very useful tool in the design of drugs with optimized pharmacological properties. In the field of the carbohydrates,… read more here.
Keywords: labelled sp2; sp2; fluoro labelled; immunomodulatory properties ... See more keywords